Application of digital pathology‐based advanced analytics of tumour microenvironment organisation to predict prognosis and therapeutic response

X Fu, E Sahai, A Wilkins - The Journal of Pathology, 2023 - Wiley Online Library
In recent years, the application of advanced analytics, especially artificial intelligence (AI), to
digital H&E images, and other histological image types, has begun to radically change how …

Dual-stream multiple instance learning network for whole slide image classification with self-supervised contrastive learning

B Li, Y Li, KW Eliceiri - … of the IEEE/CVF conference on …, 2021 - openaccess.thecvf.com
We address the challenging problem of whole slide image (WSI) classification. WSIs have
very high resolutions and usually lack localized annotations. WSI classification can be cast …

Artificial intelligence and cellular segmentation in tissue microscopy images

MS Durkee, R Abraham, MR Clark, ML Giger - The American journal of …, 2021 - Elsevier
With applications in object detection, image feature extraction, image classification, and
image segmentation, artificial intelligence is facilitating high-throughput analysis of image …

Diagnose like a pathologist: Transformer-enabled hierarchical attention-guided multiple instance learning for whole slide image classification

C Xiong, H Chen, JJY Sung, I King - arXiv preprint arXiv:2301.08125, 2023 - arxiv.org
Multiple Instance Learning (MIL) and transformers are increasingly popular in
histopathology Whole Slide Image (WSI) classification. However, unlike human pathologists …

Multi-scale representation attention based deep multiple instance learning for gigapixel whole slide image analysis

H Xiang, J Shen, Q Yan, M Xu, X Shi, X Zhu - Medical Image Analysis, 2023 - Elsevier
Recently, convolutional neural networks (CNNs) directly using whole slide images (WSIs) for
tumor diagnosis and analysis have attracted considerable attention, because they only …

Label-efficient deep learning in medical image analysis: Challenges and future directions

C Jin, Z Guo, Y Lin, L Luo, H Chen - arXiv preprint arXiv:2303.12484, 2023 - arxiv.org
Deep learning has seen rapid growth in recent years and achieved state-of-the-art
performance in a wide range of applications. However, training models typically requires …

Collagen fiber centerline tracking in fibrotic tissue via deep neural networks with variational autoencoder-based synthetic training data generation

H Park, B Li, Y Liu, MS Nelson, HM Wilson… - Medical Image …, 2023 - Elsevier
The role of fibrillar collagen in the tissue microenvironment is critical in disease contexts
ranging from cancers to chronic inflammations, as evidenced by many studies. Quantifying …

Mueller matrix imaging for collagen scoring in mice model of pregnancy

HR Lee, I Saytashev, VN Du Le, M Mahendroo… - Scientific reports, 2021 - nature.com
Preterm birth risk is associated with early softening of the uterine cervix in pregnancy due to
the accelerated remodeling of collagen extracellular matrix. Studies of mice model of …

Microenvironment-mediated cancer dormancy: Insights from metastability theory

S Bakhshandeh, C Werner, P Fratzl… - Proceedings of the …, 2022 - National Acad Sciences
Dormancy is an evolutionarily conserved protective mechanism widely observed in nature. A
pathological example is found during cancer metastasis, where cancer cells disseminate …

Single image super-resolution for whole slide image using convolutional neural networks and self-supervised color normalization

B Li, A Keikhosravi, AG Loeffler, KW Eliceiri - Medical Image Analysis, 2021 - Elsevier
High-quality whole slide scanners used for animal and human pathology scanning are
expensive and can produce massive datasets, which limits the access to and adoption of …