Nanobodies: next generation of cancer diagnostics and therapeutics

EY Yang, K Shah - Frontiers in Oncology, 2020 - frontiersin.org
The development of targeted medicine has greatly expanded treatment options and spurred
new research avenues in cancer therapeutics, with monoclonal antibodies (mAbs) emerging …

[PDF][PDF] Nanobody—A versatile tool for cancer diagnosis and therapeutics

M Liu, L Li, D Jin, Y Liu - Wiley Interdisciplinary Reviews …, 2021 - researchgate.net
In spite of the successful use of monoclonal antibodies (mAbs) in clinic for tumor treatment,
their applications are still hampered in therapeutic development due to limitations, such as …

Ligand-targeted delivery of photosensitizers for cancer treatment

P Gierlich, AI Mata, C Donohoe, RMM Brito, MO Senge… - Molecules, 2020 - mdpi.com
Photodynamic therapy (PDT) is a promising cancer treatment which involves a
photosensitizer (PS), light at a specific wavelength for PS activation and oxygen, which …

Applications of nanobodies in brain diseases

F Zheng, Y Pang, L Li, Y Pang, J Zhang… - Frontiers in …, 2022 - frontiersin.org
Nanobodies are antibody fragments derived from camelids, naturally endowed with
properties like low molecular weight, high affinity and low immunogenicity, which contribute …

[HTML][HTML] Nanobody-targeted photodynamic therapy induces significant tumor regression of trastuzumab-resistant HER2-positive breast cancer, after a single treatment …

MM Deken, MM Kijanka, IB Hernández… - Journal of controlled …, 2020 - Elsevier
Rationale A substantial number of breast cancer patients with an overexpression of the
human epidermal growth factor receptor 2 (HER2) have residual disease after neoadjuvant …

Current status and future expectations of nanobodies in oncology trials

T De Pauw, L De Mey, JM Debacker… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Monoclonal antibodies have revolutionized personalized medicine for cancer in
recent decades. Despite their broad application in oncology, their large size and complexity …

The impact of nanobody density on the targeting efficiency of PEGylated liposomes

BS Mesquita, MHAM Fens, A Di Maggio… - International Journal of …, 2022 - mdpi.com
Nanoparticles (NPs) are commonly modified with tumor-targeting moieties that recognize
proteins overexpressed on the extracellular membrane to increase their specific interaction …

A Novel Nanobody–Photosensitizer Conjugate for Hypoxia Resistant Photoimmunotherapy

T Xiong, Q Peng, Y Chen, M Li, J Du… - Advanced Functional …, 2021 - Wiley Online Library
As a non‐invasive treatment modality, photodynamic therapy has been a potential
therapeutic method for metastatic and non‐metastatic tumors. In order to further improve the …

[HTML][HTML] Near-infrared photoimmunotherapy: design and potential applications for cancer treatment and beyond

D Wei, J Qi, MR Hamblin, X Wen, X Jiang, H Yang - Theranostics, 2022 - ncbi.nlm.nih.gov
Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed cancer treatment
modality based on a target-specific photosensitizer conjugate (TSPC) composed of an NIR …

[HTML][HTML] Fighting Staphylococcus aureus infections with light and photoimmunoconjugates

M Bispo, A Anaya-Sanchez, S Suhani, EJM Raineri… - JCI insight, 2020 - ncbi.nlm.nih.gov
Infections caused by multidrug-resistant Staphylococcus aureus, especially methicillin-
resistant S. aureus (MRSA), are responsible for high mortality and morbidity worldwide …