Differentiation therapy of acute myeloid leukemia
E Gocek, E Marcinkowska - Cancers, 2011 - mdpi.com
Acute Myeloid Leukemia (AML) is a predominant acute leukemia among adults,
characterized by accumulation of malignantly transformed immature myeloid precursors. A …
characterized by accumulation of malignantly transformed immature myeloid precursors. A …
The Use of 1α,25-Dihydroxyvitamin D3 as an Anticancer Agent
E Marcinkowska, GR Wallace, G Brown - International Journal of …, 2016 - mdpi.com
The notion that vitamin D can influence the incidence of cancer arose from epidemiological
studies. The major source of vitamin D in the organism is skin production upon exposure to …
studies. The major source of vitamin D in the organism is skin production upon exposure to …
MicroRNA-32 Upregulation by 1,25-Dihydroxyvitamin D3 in Human Myeloid Leukemia Cells Leads to Bim Targeting and Inhibition of AraC-Induced Apoptosis
E Gocek, X Wang, X Liu, CG Liu, GP Studzinski - Cancer research, 2011 - AACR
Dihydroxyvitamin D3 (1, 25D) used to treat human acute myeloid leukemia (AML) cells
induces features of normal monocytes, but the mechanisms underlying this response are not …
induces features of normal monocytes, but the mechanisms underlying this response are not …
Low 25(OH) vitamin D3 levels are associated with adverse outcome in newly diagnosed, intensively treated adult acute myeloid leukemia
BACKGROUND Several studies have suggested that low 25 (OH) vitamin D3 levels may be
prognostic in some malignancies, but no studies have evaluated their impact on treatment …
prognostic in some malignancies, but no studies have evaluated their impact on treatment …
Regulation of Expression of CEBP Genes by Variably Expressed Vitamin D Receptor and Retinoic Acid Receptor α in Human Acute Myeloid Leukemia Cell Lines
A Marchwicka, E Marcinkowska - International journal of molecular …, 2018 - mdpi.com
All-trans-retinoic acid (ATRA) and 1α, 25-dihydroxyvitamin D (1, 25D) are potent inducers of
differentiation of myeloid leukemia cells. During myeloid differentiation specific transcription …
differentiation of myeloid leukemia cells. During myeloid differentiation specific transcription …
Ex vivo drug screening defines novel drug sensitivity patterns for informing personalized therapy in myeloid neoplasms
MA Spinner, A Aleshin, MT Santaguida… - Blood …, 2020 - ashpublications.org
Precision medicine approaches such as ex vivo drug sensitivity screening (DSS) are
appealing to inform rational drug selection in myelodysplastic syndromes (MDSs) and acute …
appealing to inform rational drug selection in myelodysplastic syndromes (MDSs) and acute …
Vitamin D derivatives in acute myeloid leukemia: The matter of selecting the right targets
E Marcinkowska - Nutrients, 2022 - mdpi.com
Acute myeloid leukemia (AML) is an aggressive and often fatal hematopoietic malignancy. A
very attractive way to treat myeloid leukemia, called “differentiation therapy”, was proposed …
very attractive way to treat myeloid leukemia, called “differentiation therapy”, was proposed …
Perspectives of differentiation therapies of acute myeloid leukemia: the search for the molecular basis of patients' variable responses to 1, 25-dihydroxyvitamin D and …
A Marchwicka, M Cebrat, P Sampath… - Frontiers in …, 2014 - frontiersin.org
The concept of differentiation therapy of cancer is~ 40 years old. Despite many encouraging
results obtained in laboratories, both in vitro and in vivo studies, the only really successful …
results obtained in laboratories, both in vitro and in vivo studies, the only really successful …
Opposite regulation of vitamin D receptor by ATRA in AML cells susceptible and resistant to vitamin D-induced differentiation
Some leukemic cell lines can be driven to differentiate to monocyte-like cells by 1, 25-
dihydroxyvitamin D3 (1, 25D) and to granulocyte-like cells by all-trans retinoic acid (ATRA) …
dihydroxyvitamin D3 (1, 25D) and to granulocyte-like cells by all-trans retinoic acid (ATRA) …
Diverse regulation of vitamin D receptor gene expression by 1, 25-dihydroxyvitamin D and ATRA in murine and human blood cells at early stages of their …
Vitamin D receptor (VDR) is present in multiple blood cells, and the hormonal form of vitamin
D, 1, 25-dihydroxyvitamin D (1, 25D) is essential for the proper functioning of the immune …
D, 1, 25-dihydroxyvitamin D (1, 25D) is essential for the proper functioning of the immune …