RNA-binding proteins and their role in kidney disease

L Seufert, T Benzing, M Ignarski… - Nature Reviews …, 2022 - nature.com
RNA-binding proteins (RBPs) are of fundamental importance for post-transcriptional gene
regulation and protein synthesis. They are required for pre-mRNA processing and for RNA …

Chromatin accessibility analysis and architectural profiling of human kidneys reveal key cell types and a regulator of diabetic kidney disease

M Eun, D Kim, SI Shin, HO Yang, KD Kim, SY Choi… - Kidney International, 2024 - Elsevier
Diabetes is the leading cause of kidney disease that progresses to kidney failure. However,
the key molecular and cellular pathways involved in diabetic kidney disease (DKD) …

APOBEC-1 Complementation Factor: From RNA Binding to Cancer

L Wang, Q Cheng - Cancer Control, 2024 - journals.sagepub.com
Background APOBEC-1 complementation factor (A1CF) and Apolipoprotein B mRNA editing
enzyme, catalytic polypeptide-1 (APOBEC-1) constitute the minimal proteins necessary for …

APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo

EM Snyder, C McCarty, A Mehalow, KL Svenson… - Rna, 2017 - rnajournal.cshlp.org
Editing of the human and murine ApoB mRNA by APOBEC1, the catalytic enzyme of the
protein complex that catalyzes C-to-U RNA editing, creates an internal stop codon within the …

A1CF Binding to the p65 Interaction Site on NKRF Decreased IFN-β Expression and p65 Phosphorylation (Ser536) in Renal Carcinoma Cells

Y Liu, J Yang, D Weng, Y Xie - International Journal of Molecular …, 2024 - mdpi.com
Apobec-1 complementation factor (A1CF) functions as an RNA-binding cofactor for APO-
BEC1-mediated C-to-U conversion during RNA editing and as a hepatocyte-specific …

High APOBEC1 complementation factor expression positively modulates the proliferation, invasion, and migration of endometrial cancer cells through regulating P53 …

Q Liu, CY Chen, GL Chen - Cancer biotherapy & …, 2022 - liebertpub.com
Background: APOBEC1 complementation factor (A1CF) is a component of the
apolipoprotein-B messenger RNA editing complex that participates in various cellular …

A1CF-Axin2 signal axis regulates apoptosis and migration in Wilms tumor-derived cells through Wnt/β-catenin pathway

D Ni, J Liu, Y Hu, Y Liu, Y Gu, Q Zhou, Y Xie - In Vitro Cellular & …, 2019 - Springer
A1CF, a complementary factor of APOBEC-1, is involved in many cellular processes for its
mRNA editing role, such as cell proliferation, apoptosis, and migration. Here, we explored …

Apobec-1 complementation factor regulates cell migration and apoptosis through Dickkopf1 by acting on its 3′ untranslated region in MCF7 cells

X Yan, Q Li, D Ni, Y Xie, Q He, Q Wan, Y Liu… - Tumor …, 2017 - journals.sagepub.com
A1CF (apobec-1 complementation factor) acts as a component of the apolipoprotein-B
messenger RNA editing complex. Previous researches mainly focused on its post …

[HTML][HTML] miRNA-142-3p 对肺泡巨噬细胞炎症过程的负向调控及其机制

江伟伟, 李文放 - 第二军医大学学报, 2017 - html.rhhz.net
目的探索miRNA-142-3p (miR-142-3p) 对脂多糖(LPS) 诱导的大鼠肺泡巨噬细胞炎症反应的负
向调控作用及其可能机制. 方法用100 ng/mL LPS 诱导肺泡巨噬细胞NR8383, 实时定量PCR …