Platelets are involved in life-sustaining processes such as hemostasis, wound healing,
atherothrombosis and angiogenesis. Mechanical trauma to blood vessels causes platelet …

The actin filament network fills the cytoplasm of unstimulated platelets and connects with a
submembranous latticework of short cross-linked actin filaments, known as the membrane …

ALTHOUGH vinculin is present at all sites of F-actin attachment to plasma membranes1 and
is required for linkage of myofibrils to sarcolemma2, it is unclear how it promotes attachment …

Mouse F9 embryonic carcinoma 5.51 cells that lack the cytoskeletal protein vinculin spread
poorly on extracellular matrix compared with wild-type F9 cells or two vinculin-transfected …

We have determined the sequence of chicken talin (2,541 amino acids, M r 271,881) which
is very similar (89% identity) to that of the mouse protein. Alignments with the …

Intracellular vesicles destined to fuse with the plasma membrane and secrete their contents
must have a mechanism for specifically interacting with the appropriate target membrane …

In epithelial cells, α-, β-, and γ-catenin are involved in linking the peripheral microfilament
belt to the transmembrane protein E-cadherin. α-Catenin exhibits sequence homologies …

The interaction between the cytoskeletal proteins talin and vinculin plays a key role in
integrin-mediated cell adhesion and migration. Three vinculin binding sites (VBS1-3) have …

Three independent lines of evidence demonstrate an interaction between the head and tail
domains of vinculin. First, both the purified 30-kDa tail fragment and a fusion protein …

We have used gene disruption to isolate two talin (−/−) ES cell mutants that contain no intact
talin. The undifferentiated cells (a) were unable to spread on gelatin or laminin and grew as …