Proteomic studies of human Alzheimer's disease brain tissue have potential to identify
protein changes that drive disease, and to identify new drug targets. Here, we analyse 38 …

Accumulation of phosphorylated tau is a key pathological feature of Alzheimer's disease.
Phosphorylated tau accumulation causes synaptic impairment, neuronal dysfunction and …

Amyloid plaques contain many proteins in addition to beta amyloid (Aβ). Previous studies
examining plaque-associated proteins have shown these additional proteins are important; …

Alzheimer's Disease (AD) is a form of progressive dementia involving cognitive impairment,
loss of learning and memory. Different proteins (such as amyloid precursor protein (APP), β …

Neuroinflammation is considered a key pathological process in neurodegenerative diseases
of aging, including Alzheimer's disease (AD). Many studies have defined phenotypes of …

Spatial omics technologies have become powerful methods to provide valuable insights into
cells and tissues within a complex context, significantly enhancing our understanding of the …

Background NLRP3 inflammasome-mediated neuroinflammation plays a critical role in the
pathogenesis and development of Alzheimer's disease (AD). Microglial autophagic …

Epilepsy is a common neurological disorder affecting over 70 million people worldwide, with
a high rate of pharmaco-resistance, diverse comorbidities including progressive cognitive …

Glial fibrillary acidic protein (GFAP) is an intermediate filament structural protein involved in
cytoskeleton assembly and integrity, expressed in high abundance in activated glial cells …

Today, neurodegenerative diseases have become a remarkable public health challenge
due to their direct relation with aging. Accordingly, understanding the molecular and cellular …