Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …

Seizures and other forms of neurovolatility are emerging as druggable prodromal
mechanisms that link traumatic brain injury (TBI) to the progression of later dementias. TBI …

The blood-brain barrier (BBB) is dysfunctional in temporal lobe epilepsy (TLE). In this
regard, microvascular changes are likely present. The aim of this review is to provide an …

The potassium channel opening drugs flupirtine and retigabine have been withdrawn from
the market due to occasional drug-induced liver injury (DILI) and tissue discoloration …

Despite significant advances in our understanding of the pathophysiology of multiple
sclerosis (MS), knowledge about contribution of individual ion channels to axonal …

The rising interest in Kv7 modulators originates from their ability to evoke fundamental
electrophysiological perturbations in a tissue-specific manner. A large number of therapeutic …

K v 7 (“M-type,” KCNQ) K+ currents, play dominant roles in controlling neuronal excitability.
They act as a “brake” against hyperexcitable states in the central and peripheral nervous …

Glycogen synthase kinase 3beta (GSK-3β) is an enzyme with a variety of cellular functions
in addition to the regulation of glycogen metabolism. In the central nervous system, different …

Spreading depolarization is a slowly propagating wave of massive cellular depolarization
associated with acute brain injury and migraine aura. Genetic studies link depolarizing …

We investigated whether pharmacological increase of “M-type”(KCNQ, Kv7) K+ channel
currents by the M-channel opener, retigabine (RTG), acutely after repetitive traumatic brain …