Peripheral nerve injury may result in injury without gaps or injury with gaps between nerve
stumps. In the presence of a nerve defect, the placement of an autologous nerve graft is the …

We review data showing that peripheral nerve injuries (PNIs) that involve the loss of a nerve
segment are the most common type of traumatic injury to nervous systems. Segmental-loss …

Repair of large nerve defects with acellular nerve allografts (ANAs) is an appealing
alternative to autografting and allotransplantation. ANAs have been shown to be similar to …

Allogeneic hand transplantation is now a clinical reality. While results have been
encouraging, acute rejection rates are higher than in their solid-organ counterparts. In …

Administration of FK506, an FDA approved immunosuppressant, has been shown to
enhance nerve regeneration following peripheral nerve injuries. However, the severe side …

Background Hand-transplantation and improvements in the field of prostheses opened new
frontiers in restoring hand function in below-elbow amputees. Both concepts aim at restoring …

Vascularized composite allotransplants (VCAs) have unique properties because of diverse
tissue components transplanted en mass as a single unit. In addition to surgery, this type of …

Psychosocial factors are important elements in the assessment and follow-up care for
vascularized composite allotransplantation (VCA) and require multidisciplinary evaluation …

In the last 12 years, the Louisville CTA program has screened more than 600 interested
hand transplant candidates and transplanted 6 patients with 7 hand allografts. The Louisville …

A number of potential approaches aim to optimize functional recovery after spinal cord
injury. They include minimizing the progression of secondary injury, manipulating the …