Life implies movement. Most forms of movement in the living world are powered by tiny
protein machines known as molecular motors. Among the best known are motors that use …

Myosins constitute a large superfamily of actin-dependent molecular motors. Phylogenetic
analysis currently places myosins into 15 classes. The conventional myosins which form …

Abstract A balanced (1; 11)(q42. 1; q14. 3) translocation segregates with schizophrenia and
related psychiatric disorders in a large Scottish family (maximum LOD= 6.0). We hypothesize …

Interactions between microtubules and actin are a basic phenomenon that underlies many
fundamental processes in which dynamic cellular asymmetries need to be established and …

The dynamic rearrangement of cell-cell adhesion is one of the major physiological events in
tissue development and tumor metastasis. Polarized cell migration, another key event, is a …

We recently showed that substrate contact sites in living fibroblasts are specifically targeted
by microtubules (Kaverina, I., K. Rottner, and JV Small. 1998. J. Cell Biol. 142: 181–190) …

In diverse cell types, microtubule (MT) and actin filament networks cooperate functionally
during a wide variety of processes, including vesicle and organelle transport, cleavage …

EB1 is an evolutionarily conserved protein that localizes to the plus ends of growing
microtubules. In yeast, the EB1 homologue (BIM1) has been shown to modulate microtubule …

Early in evolution, the diversification of membrane-bound compartments that characterize
eukaryotic cells was accompanied by the elaboration of molecular machineries that mediate …

Directional cell migration is a fundamental process in all organisms that is stringently
regulated during tissue development, chemotaxis and wound healing. Migrating cells have a …