Break-induced replication (BIR) is a pathway that repairs one-ended double-strand breaks
(DSBs). For decades, yeast model systems offered the only opportunities to study eukaryotic …

Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …

Aberrant DNA replication is a major source of the mutations and chromosome
rearrangements that are associated with pathological disorders. When replication is …

Recent advances in DNA synthesis technology have enabled the construction of novel
genetic pathways and genomic elements, furthering our understanding of system-level …

Genomes are transmitted faithfully from dividing cells to their offspring. Changes that occur
during DNA repair, chromosome duplication, and transmission or via recombination provide …

Genomic instability in the form of mutations and chromosome rearrangements is usually
associated with pathological disorders, and yet it is also crucial for evolution. Two types of …

Repeated elements can be widely abundant in eukaryotic genomes, composing more than
50% of the human genome, for example. It is possible to classify repeated sequences into …

Chromosomal fragile sites are specific loci that preferentially exhibit gaps and breaks on
metaphase chromosomes following partial inhibition of DNA synthesis. Their discovery has …

Sexual recombination drives genetic diversity in eukaryotic genomes and fosters adaptation
to novel environmental challenges. Although strictly asexual microorganisms are often …

A network governing DNA integrity was identified in yeast by a global genetic analysis of
synthetic fitness or lethality defect (SFL) interactions. Within this network, 16 functional …