As a new type of injectable biomaterials, functional microspheres have attracted increasing
attention in tissue regeneration because they possess some advantageous properties …

Presently, there is a high paucity of bone grafts in the United States and worldwide.
Regenerating bone is of prime concern due to the current demand of bone grafts and the …

Despite the high regenerative capacity of bone tissue, there are some cases where bone
repair is insufficient for a complete functional and structural recovery after damage. Current …

Bone is a complex tissue with a variety of functions, such as providing mechanical stability
for locomotion, protection of the inner organs, mineral homeostasis and haematopoiesis. To …

Rheumatoid arthritis (RA) is a chronic, inflammatory, and systemic autoimmune disease that
affects the connective tissue and primarily the joints. If not treated, RA ultimately leads to …

Three‐dimensional scaffolds like hydrogels can be employed as cell carriers for in vitro or in
vivo colonization and have become a major research topic to replace damaged tissue. In the …

Mesenchymal stem cells (MSCs), well-studied adult stem cells in various tissues, possess
multi-lineage differentiation potential and anti-inflammatory properties. MSCs have been …

Abstract Purpose of Review Novel therapies for damaged and diseased bone are being
developed in a preclinical testing process consisting of in vitro cell experiments followed by …

The intimate crosstalk between endothelial and bony cells is essential for the reconstruction
of bone tissue defects. Indeed, a successful bone repair is greatly dependent on the …

Adenovirus-mediated gene therapy is a promising tool in bone regenerative medicine. In
this work, gene-activated matrices (GAMs) composed of (1) polylactide granules (PLA) …