Genetic manipulation approaches to enhance the clinical application of NK cell-based immunotherapy

A Maia, M Tarannum, R Romee - Stem Cells Translational …, 2024 - academic.oup.com
Natural killer (NK) cells are a subset of cytotoxic lymphocytes within the innate immune
system. While they are naturally cytotoxic, genetic modifications can enhance their tumor …

Haploidentical hematopoietic cell transplantation as a platform for natural killer cell immunotherapy

R Duléry, S Piccinelli, MS Beg, JE Jang… - American Journal of …, 2024 - Wiley Online Library
An innovative approach is crucially needed to manage relapse after allogeneic
hematopoietic cell transplantation (HCT) in patients with advanced hematological …

[HTML][HTML] iPSC-mediated genetic manipulation promotes natural killer cell-centered cancer immunotherapy

Y Zheng, Y Zhang, Z Yang, WK Chan… - Microbes & …, 2024 - accscience.com
Natural killer (NK) cells demonstrate potent cytotoxic activities and the capacity to secrete
cytokines. Their distinctive capability to trigger cell death, bypassing the need for major …