Synthesis, characterization, crystal structures, theoretical calculations and biological evaluations of novel substituted tacrine derivatives as cholinesterase and …
The six and seven hydrocycle membered disilylanilino acridine (tacrine) analogues (9–11)
were synthesized by one-pot procedures. The structures of novel silyl tacrine derivatives …
were synthesized by one-pot procedures. The structures of novel silyl tacrine derivatives …
Quinoline‐based promising anticancer and antibacterial agents, and some metabolic enzyme inhibitors
A series of substituted quinolines was screened for their antiproliferative, cytotoxic,
antibacterial activities, DNA/protein binding affinity, and anticholinergic properties by using …
antibacterial activities, DNA/protein binding affinity, and anticholinergic properties by using …
Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents
Due to a great deal of biological activities, quinoline derivatives have drawn attention for
synthesis and biological activities in the search for new anticancer drug development. In this …
synthesis and biological activities in the search for new anticancer drug development. In this …
Synthesis, characterization, and SAR of arylated indenoquinoline‐based cholinesterase and carbonic anhydrase inhibitors
We report the synthesis of bromoindenoquinolines (15a–f) by Friedlander reactions in low
yields (13–50%) and the conversion of the corresponding phenyl‐substituted …
yields (13–50%) and the conversion of the corresponding phenyl‐substituted …
Novel piperazine and morpholine substituted quinolines: Selective synthesis through activation of 3, 6, 8-tribromoquinoline, characterization and their some metabolic …
Regioselective routes are described for convenient preparation of novel
piperazine/morpholine substituted quinoline derivatives at C-3, C-6 and C-8 starting with 3 …
piperazine/morpholine substituted quinoline derivatives at C-3, C-6 and C-8 starting with 3 …
Arylated quinoline and tetrahydroquinolines: Synthesis, characterization and their metabolic enzyme inhibitory and antimicrobial activities
The aims of this study are to synthesize and characterize some new phenyl quinoline
derivatives and to determine the activities of them and the recently prepared substituted …
derivatives and to determine the activities of them and the recently prepared substituted …
[HTML][HTML] Functionalized methoxy quinoline derivatives: Experimental and in silico evaluation as new antiepileptic, anti-Alzheimer, antibacterial and antifungal drug …
The objective of this study was to assess the inhibitory effects of newly synthesized quinoline
derivatives on human carbonic anhydrase I and II (hCA I and II), as well as …
derivatives on human carbonic anhydrase I and II (hCA I and II), as well as …
Decision making for promising quinoline‐based anticancer agents through combined methodology
During the development of effective drugs for the treatment of cancer, one of the most
important tasks is to identify effective drug candidates having maximum antiproliferation and …
important tasks is to identify effective drug candidates having maximum antiproliferation and …
Total synthesis of natural benzoazepinoquinolinone alkaloid irrepairzepine via Au (I)-catalyzed cycloisomerization and regioselective functionalization
J Park, S Lee, YT Han - Tetrahedron Letters, 2024 - Elsevier
Abstract Irrepairzepine (1), a unique benzoazepinoquinolinone alkaloid isolated from an
endophytic fungus, exhibits synthetic lethality targeting in PTEN-deficient glioblastoma cells …
endophytic fungus, exhibits synthetic lethality targeting in PTEN-deficient glioblastoma cells …
Synthesis of aryl-substituted quinolines and tetrahydroquinolines through Suzuki–Miyaura coupling reactions
S Ökten - Journal of Chemical Research, 2019 - journals.sagepub.com
The synthesis and characterization of substituted (trifluoromethoxy, thiomethyl, and methoxy)
phenyl quinolines is described. Dichlorobis (triphenylphosphine) palladium (II)-catalyzed …
phenyl quinolines is described. Dichlorobis (triphenylphosphine) palladium (II)-catalyzed …