Executive summary The number of older people, including those living with dementia, is
rising, as younger age mortality declines. However, the age-specific incidence of dementia …

Frailty is a multiply determined, age-related state of increased risk for adverse health
outcomes. We review how the degree of frailty conditions the development of late-life …

For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …

Importance Delirium is associated with increased hospital costs, health care complications,
and increased mortality. Long-term consequences of delirium on cognition have not been …

Abstract Since 1989, four Canadian Consensus Conferences on the Diagnosis and
Treatment of Dementia (CCCDTD) have provided evidence‐based dementia guidelines for …

Mobile health technologies (wearable, portable, body-fixed sensors, or domestic-integrated
devices) that quantify mobility in unsupervised, daily living environments are emerging as …

The ageing brain is vulnerable to a wide array of neuropathologies. Prior work estimated
that the three most studied of these, Alzheimer's disease, infarcts, and Lewy bodies, account …

The renin–angiotensin system (RAS) was initially considered to be part of the endocrine
system regulating water and electrolyte balance, systemic vascular resistance, blood …

Frailty can be viewed as a state of physiological decline that increases susceptibility to
adverse health outcomes. This loss of physiological reserve means that even small stressors …

Background Dementia is associated with a high burden of dependency and disability.
Physical frailty (hereafter referred to as frailty) is a multisystem dysregulation that has been …