Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Mechanical hallmarks of fibrotic microenvironments are both outcomes and causes of
fibrosis progression. Understanding how cells sense and transmit mechanical cues in the …

Stem cells mechanosense the stiffness of their microenvironment, which impacts
differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix …

The nucleus is physically linked to the cytoskeleton, adhesions, and extracellular matrix—all
of which sustain forces, but their relationships to DNA damage are obscure. We show that …

Cortical stiffness is an important cellular property that changes during migration, adhesion
and growth. Previous atomic force microscopy (AFM) indentation measurements of cells …

Mesenchymal stromal cells (MSCs) modulate immune cells to ameliorate multiple
inflammatory pathologies. Biophysical signals that regulate this process are poorly defined …

Extracellular biophysical cues have a profound influence on a wide range of cell behaviors,
including growth, motility, differentiation, apoptosis, gene expression, adhesion, and signal …

The nucleus in many cell types is a stiff organelle, but fat-filled lipid droplets (FDs) in
cytoplasm are seen to indent and displace the nucleus. FDs are phase-separated liquids …

Induced pluripotent stem cells (iPSCs) have emerged as a key component of cardiac tissue
engineering, enabling studies of cardiovascular disease mechanisms, drug responses, and …

Background & Aims Liver stiffness is increased in advanced chronic liver disease (ACLD)
and accurately predicts prognosis in this population. Recent data suggest that extracellular …