Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …

Abstract In 1964, Vincent Allfrey and colleagues reported the identification of histone
acetylation and with deep insight proposed a regulatory role for this protein modification in …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Modern techniques in molecular biology, genomics, and mass spectrometry–based
proteomics have identified a large number of novel histone posttranslational modifications …

Abstract Bromodomain protein 4 (BRD4) is a chromatin-binding protein implicated in cancer
and autoimmune diseases that functions as a scaffold for transcription factors at promoters …

Post-translational modifications (PTM) decorate proteins to provide functional heterogeneity
to an existing proteome. The large number of known PTMs highlights the many ways that …

Histone acetylation in chromatin structure and transcription | Nature Skip to main content
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▪ Abstract Transcriptional regulation in eukaryotes occurs within a chromatin setting and is
strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well …

The tumor suppressor p53 exerts antiproliferation effects through its ability to function as a
sequence-specific DNA-binding transcription factor. Here, we demonstrate that p53 can be …

The state of chromatin (the packaging of DNA in eukaryotes) has long been recognized to
have major effects on levels of gene expression, and numerous chromatin-altering …