Predictive, preventive, and personalized medicine in breast cancer: targeting the PI3K pathway

M Tufail, JJ Hu, J Liang, CY He, WD Wan… - Journal of Translational …, 2024 - Springer
Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes
and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway …

MicroRNA-21's role in PTEN suppression and PI3K/AKT activation: Implications for cancer biology

HS Chawra, M Agarwal, A Mishra, SS Chandel… - … -Research and Practice, 2024 - Elsevier
Abstract MicroRNA-21 (miR-21) was recognized as a key figure in the intricate web of tumor
biology, with a prominent role in regulating the PTEN tumor suppressor gene and the …

Inhibitory role of bone marrow mesenchymal stem cells‐derived exosome in non‐small‐cell lung cancer: microRNA‐30b‐5p, EZH2 and PI3K/AKT pathway

T Wu, Q Tian, R Liu, K Xu, S Shi… - Journal of Cellular …, 2023 - Wiley Online Library
Exosomal microRNA (miRNA) exerts potential roles in non‐small‐cell lung cancer (NSCLC).
The current study elucidated the role of miR‐30b‐5p shuttled by bone marrow mesenchymal …

The role of mir-214-5p and mir-548-5p expressions in endometriosis

FD Ashkezari, SH Mirabutalebi… - Molecular Biology …, 2024 - Springer
Background Endometriosis is a benign gynecological disease that affects about 1% of all
women and up to 15% of women of childbearing age. To date, none of the proposed …

MicroRNA dynamics, PTEN/PI3K/AKT signaling, and their relationship to breast cancer: prospects for pharmaceuticals and natural product application

M Maniruzzaman, MRH Bhuiyan, MS Jaman… - Breast Cancer Research …, 2025 - Springer
Abstract Background Globally, Breast Cancer (BC) is the most frequent cancer in women
and has a major negative impact on the physical and emotional well-being of its patients as …

The impact of oleuropein on miRNAs regulating cell death signaling pathway in human cervical cancer cells

Z Amini‐Farsani… - Biotechnology and …, 2024 - Wiley Online Library
Cervical cancer is known as the second most pervasive malignancy in women across the
globe. The role played by microRNAs (miRNAs) in the initiation, progression, and metastasis …

Design, Synthesis and Biological Evaluation of 6-(Imidazo [1, 2-a] pyridin-6-yl) quinazoline Derivatives as Anticancer Agents via PI3Kα Inhibition

M Li, D Wang, Q Li, F Luo, T Zhong, H Wu… - International Journal of …, 2023 - mdpi.com
Aberrant expression of the phosphatidylinositol 3-kinase (PI3K) signalling pathway is often
associated with tumourigenesis, progression and poor prognosis. Hence, PI3K inhibitors …

Harnessing natural compounds to modulate miRNAs in breast cancer therapy

SH Aly, AI Abulsoud, YM Moustafa… - Functional & Integrative …, 2024 - Springer
Breast cancer's complexity and heterogeneity continue to present significant challenges in
its treatment and management. Emerging research has underscored the pivotal role of …

[HTML][HTML] Emerging roles of non-coding RNAs in modulating the PI3K/Akt pathway in cancer

M Hashemi, EM Khosroshahi, S Asadi, M Tanha… - Non-coding RNA …, 2024 - Elsevier
Cancer progression results from the dysregulation of molecular pathways, each with unique
features that can either promote or inhibit tumor growth. The complexity of carcinogenesis …

Expression level of miR-548aa in tissue samples of patients with colorectal cancer

AA Arabzadeh, M Farzollahpour… - Molecular Biology …, 2025 - Springer
Background The pathogenesis of colorectal cancer (CRC) is influenced by various risk
factors, and genetic alterations in progression of colon polyps. The expression patterns of …