Strategic approaches to optimizing peptide ADME properties

L Di - The AAPS journal, 2015 - Springer
Abstract Development of peptide drugs is challenging but also quite rewarding. Five
blockbuster peptide drugs are currently on the market, and six new peptides received first …

Insect natural products and processes: new treatments for human disease

NA Ratcliffe, CB Mello, ES Garcia, TM Butt… - Insect biochemistry and …, 2011 - Elsevier
In this overview, some of the more significant recent developments in bioengineering natural
products from insects with use or potential use in modern medicine are described, as well as …

Current challenges in peptide-based drug discovery

L Otvos Jr, JD Wade - Frontiers in chemistry, 2014 - frontiersin.org
The central event of each signaling step in biology is biomolecular recognition.
Notwithstanding the importance of nucleic acids, carbohydrates, or lipids in ligand-target …

Serum stabilities of short tryptophan-and arginine-rich antimicrobial peptide analogs

LT Nguyen, JK Chau, NA Perry, L de Boer, SAJ Zaat… - PloS one, 2010 - journals.plos.org
Background Several short antimicrobial peptides that are rich in tryptophan and arginine
residues were designed with a series of simple modifications such as end capping and …

Proline-rich antimicrobial peptides: converging to a non-lytic mechanism of action

M Scocchi, A Tossi, R Gennaro - Cellular and Molecular Life Sciences, 2011 - Springer
Proline-rich antimicrobial peptides are a group of cationic host defense peptides of
vertebrates and invertebrates characterized by a high content of proline residues, often …

[图书][B] Microwave heating as a tool for sustainable chemistry

NE Leadbeater - 2010 - taylorfrancis.com
Shorter reaction times, higher product yields, and enhanced selectivity are some of the
advantages microwave heating has over conventional methods, causing its use to transition …

Porcine β-defensin 2 attenuates inflammation and mucosal lesions in dextran sodium sulfate–induced colitis

F Han, H Zhang, X Xia, H Xiong, D Song… - The Journal of …, 2015 - journals.aai.org
Intestinal permeability plays a critical role in the etiopathogenesis of ulcerative colitis.
Defensins, including porcine β-defensin (pBD) 2, are crucial antimicrobial peptides for gut …

Lights and shadows on the therapeutic use of antimicrobial peptides

D Bellotti, M Remelli - Molecules, 2022 - mdpi.com
The emergence of antimicrobial-resistant infections is still a major concern for public health
worldwide. The number of pathogenic microorganisms capable of resisting common …

Gold nanoparticle-DNA aptamer conjugate-assisted delivery of antimicrobial peptide effectively eliminates intracellular Salmonella enterica serovar Typhimurium

JH Yeom, B Lee, D Kim, J Lee, S Kim, J Bae, Y Park… - Biomaterials, 2016 - Elsevier
Antimicrobial peptides (AMPs) are a promising new class of antibacterial compounds.
However, their applications in the treatment of intracellular pathogenic bacteria have been …

[HTML][HTML] The effect of lipidation and glycosylation on short cationic antimicrobial peptides

E Grimsey, DWP Collis, R Mikut, K Hilpert - Biochimica et Biophysica Acta …, 2020 - Elsevier
The global health threat surrounding bacterial resistance has resulted in antibiotic
researchers shifting their focus away from 'traditional'antibiotics and concentrating on other …