An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …

Background Obesity and its associated disorders are becoming a major health issue in
many countries. The resulting low-grade inflammation not only affects the periphery but also …

The gut microbiota generates a huge pool of unknown metabolites, and their identification
and characterization is a key challenge in metabolomics. However, there are still gaps on …

Background Although obesity is caused by different factors, individual susceptibility to
obesity differs among people under the same circumstances. The microbiota in the caecum …

Mass spectrometry-based quantitative lipidomics is an emerging field aiming to uncover the
intricate relationships between lipidomes and disease development. However, quantifying …

Depression is a serious disease that has considerable impact on lipid metabolism and
inflammatory responses. Recent studies have shown that leptin, which is well known as a …

Obesity caused by overnutrition is a major risk factor for non-alcoholic fatty liver disease
(NAFLD). Several lipid intermediates such as fatty acids, glycerophospholipids and …

Aims Probiotics and their metabolites (SCFA) can regulate energy homeostasis. The present
study thus evaluates the synergistic effect of probiotic Enterococcus faecalis AG5 on HFD …

There is growing evidence that over consumption of high-fat foods and insulin resistance
may alter hippocampal-dependent cognitive function. To study the individual contributions of …

Background Although there is strong evidence linking triglyceride to high-density lipoprotein
cholesterol (TG/HDL-C) ratio to insulin resistance and diabetes mellitus, its clinical …