Although DNA methylation was originally thought to only affect transcription, emerging
evidence shows that it also regulates alternative splicing. Exons, and especially splice sites …

The nuclear genomes of vertebrates are mosaics of isochores, very long stretches (≫
300kb) of DNA that are homogeneous in base composition and are compositionally …

Mobile genetic elements (MEs) are heritable mutagens that recursively generate structural
variants (SVs). ME variants (MEVs) are difficult to genotype and integrate in statistical …

908 N. Galtier et al. metes averaged over germ cells remain Mendelian. If, however, the
repair process is biased toward, say, G: C pairs, then allele frequencies would evolve in a …

An analysis of dinucleotide frequencies was carried out on DNAs from insects and
mammals, as well as on large DNA sequences from the genomes of Drosophila …

DNA methylation is known to regulate transcription and was recently found to be involved in
exon recognition via cotranscriptional splicing. We recently observed that exon–intron …

The eukaryotic genome has undergone a series of epidemics of amplification of mobile
elements that have resulted in most eukaryotic genomes containing much more of this …

Epigenomic studies aim to define the location and nature of the genomic sequences that are
epigenetically modified. Much progress has been made towards whole-genome epigenetic …

Unraveling the evolutionary forces responsible for variations of neutral substitution patterns
among taxa or along genomes is a major issue in the identification of functional sequence …

Lactation, an important characteristic of mammalian reproduction, has evolved by exploiting
a diversity of strategies across mammals. Comparative genomics and transcriptomics …