APOBEC enzymes as targets for virus and cancer therapy
Human DNA cytosine-to-uracil deaminases catalyze mutations in both pathogen and
cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human …
cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human …
Novel targets for HIV therapy
There are currently 25 drugs belonging to 6 different inhibitor classes approved for the
treatment of human immunodeficiency virus (HIV) infection. However, new anti-HIV agents …
treatment of human immunodeficiency virus (HIV) infection. However, new anti-HIV agents …
Prediction of HIV-1 virus-host protein interactions using virus and host sequence motifs
Background Host protein-protein interaction networks are altered by invading virus proteins,
which create new interactions, and modify or destroy others. The resulting network topology …
which create new interactions, and modify or destroy others. The resulting network topology …
Small-molecule inhibition of human immunodeficiency virus type 1 replication by targeting the interaction between Vif and ElonginC
T Zuo, D Liu, W Lv, X Wang, J Wang, M Lv… - Journal of …, 2012 - Am Soc Microbiol
The HIV-1 viral infectivity factor (Vif) protein is essential for viral replication. Vif recruits
cellular ElonginB/C-Cullin5 E3 ubiquitin ligase to target the host antiviral protein …
cellular ElonginB/C-Cullin5 E3 ubiquitin ligase to target the host antiviral protein …
Indolizine Derivatives as HIV‐1 VIF–Elongin C Interaction Inhibitors
W Huang, T Zuo, X Luo, H Jin, Z Liu… - Chemical biology & …, 2013 - Wiley Online Library
Compound 1 (VEC‐5) was identified as a potent small‐molecular HIV‐1 viron infectivity
factor inhibitor that targets the viron infectivity factor–Elongin C interaction. A structure …
factor inhibitor that targets the viron infectivity factor–Elongin C interaction. A structure …
Tumultuous relationship between the human immunodeficiency virus type 1 viral infectivity factor (Vif) and the human APOBEC-3G and APOBEC-3F restriction factors
S Henriet, G Mercenne, S Bernacchi… - Microbiology and …, 2009 - Am Soc Microbiol
The viral infectivity factor (Vif) is dispensable for human immunodeficiency virus type 1 (HIV-
1) replication in so-called permissive cells but is required for replication in nonpermissive …
1) replication in so-called permissive cells but is required for replication in nonpermissive …
Design, synthesis and biological evaluation of indolizine derivatives as HIV-1 VIF–ElonginC interaction inhibitors
W Huang, T Zuo, H Jin, Z Liu, Z Yang, X Yu, L Zhang… - Molecular …, 2013 - Springer
The HIV-1 viral infectivity factor (VIF) protein is essential for viral replication. VIF recruits
cellular ElonginB/C-Cullin5 E3 ubiquitin ligase to target the host antiviral protein …
cellular ElonginB/C-Cullin5 E3 ubiquitin ligase to target the host antiviral protein …
The dimerization domain of HIV-1 viral infectivity factor Vif is required to block virion incorporation of APOBEC3G
JH Miller, V Presnyak, HC Smith - Retrovirology, 2007 - Springer
Background The HIV-1 accessory protein known as viral infectivity factor or Vif binds to the
host defence factor human APOBEC3G (hA3G) and prevents its assembly with viral particles …
host defence factor human APOBEC3G (hA3G) and prevents its assembly with viral particles …
Advances in the structural understanding of Vif proteins
P Barraud, JC Paillart, R Marquet… - Current HIV research, 2008 - ingentaconnect.com
The multidomain HIV-1 Vif protein recruits several cellular partners to achieve neutralization
of the antiviral activity of APOBEC3 proteins. Vif neutralizes APOBEC3G and APOBEC3F …
of the antiviral activity of APOBEC3 proteins. Vif neutralizes APOBEC3G and APOBEC3F …
Strategies for inhibiting function of HIV-1 accessory proteins: a necessary route to AIDS therapy?
SN Richter, I Frasson, G Palu - Current medicinal chemistry, 2009 - ingentaconnect.com
The Human Immunodeficiency Virus (HIV) genome encodes three major structural proteins
common to all retroviruses (Gag, Pol and Env), two regulatory proteins (Tat and Rev) that are …
common to all retroviruses (Gag, Pol and Env), two regulatory proteins (Tat and Rev) that are …