Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable
cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of …

Abstract Purpose of Review Hypoxia-inducible factors (HIFs) mediate the transcription of
hundreds of genes that allow cells to adapt to hypoxic environments. In this review, we …

MALAT1 is an oncogenic long non-coding RNA that has been found to promote the
proliferation of many malignant cell types and non-malignant human umbilical vein …

Abstract The imidazobenzoxazin-5-thione MV1035, synthesized as a new sodium channel
blocker, has been tested on tumoral cells that differ for origin and for expressed Na V pool …

A wide body of evidence suggests that voltage-gated sodium channels (VGSCs) are
expressed de novo in several human carcinomas where channel activity promotes a variety …

Metastasis is the dominant cause of cancer-related mortality. Metastasis-associated with
colon cancer protein 1 (MACC1) has been proven to play a critical role in cancer metastasis …

In their seminal papers Hanahan and Weinberg described oncogenic processes a normal
cell undergoes to be transformed into a cancer cell. The functions of ion channels in the …

The normal functioning of every cell in the body depends on its bioelectric properties and
many diseases are caused by genetic and/or epigenetic dysregulation of the underlying ion …

Loss of epithelial polarity and gain in invasiveness by carcinoma cells are critical events in
the aggressive progression of cancers and depend on phenotypic transition programs such …

Interferon-induced transmembrane proteins (IFITMs) are expressed in some types of cancer.
However, their precise roles in tumor progression remain unclear. The present study …