Ovarian cancer is the most lethal gynecological malignancy. Cisplatin and its derivatives are
first‐line chemotherapeutics, and their resistance is a major hurdle in successful ovarian …

Cisplatin has been used effectively in the treatment of hepatocellular carcinoma (HCC).
Long noncoding RNAs (lncRNAs) were recently reported to contribute to the pathogenesis …

The contribution of RNA processing to tumorigenesis is understudied. Here, we report that
the human RNA debranching enzyme (hDBR1), when inappropriately regulated, induces …

Accumulation of DNA damage has been detected in the spinal cord of patients as well as in
the G93A mouse model of amyotrophic lateral sclerosis (ALS). Wild-type p53-induced …

Mice lacking wild-type p53-induced phosphatase 1 (Wip1) display male reproductive defects
including smaller testes, subfertility and spermatogenesis defects at the round-and …

Ovarian cancer (OVCA) and cervical cancer (CECA) are lethal gynecological malignancies.
Cisplatin (CDDP) and platinum derivatives are first line chemotherapeutics and their …

Wild-type p53-induced phosphatase 1 (Wip1) is a p53-inducible serine/threonine
phosphatase that switches off DNA damage checkpoint responses by the dephosphorylation …

P17 is a novel neuronal protein expressed under physiological conditions only at very low
levels in other tissues. Accumulating data indicate its crucial involvement in tumorigenic …

Effectiveness of DNA cross-linking drugs in the treatment of bladder cancer suggests that
bladder cancer cells may have harbored an insufficient cellular response to DNA cross-link …

Abstract A compromised Fanconi Anemia (FA) signaling pathway, often resulting from an
inactivated FANCD2, was recently recognized to contribute to the development of non-FA …