In this study, a series of 5-aryl-3-alkylthio-1, 2, 4-triazoles and corresponding sulfones were
prepared with the objective of developing better analgesic–antiinflammatory compounds …

For management of pain, non-steroidal anti-inflammatory drugs (NSAIDs) play a major role.
Use of NSAIDs is associated with toxicity, particularly in the gastrointestinal tract and kidney …

Substituted-1, 2, 4-triazole-5-thiones are versatile synthetic intermediates for the preparation
of several biologically active N-bridged heterocyclic compounds, given that they have two …

Starting from 3-substituted-1, 2, 4-triazole-5-thiones (1a–h), eight new 5-carbomethoxy-2-
substituted-7H-1, 2, 4-triazolo [3, 2-b]-1, 3-thiazine-7-ones (2a–h) were synthesized and …

Abstract A new series of 1, 2, 4-triazole-5-thione Mannich derivatives containing a naproxen
moiety (1a-o) was designed and synthesized to create naproxen analogs, with the aim of …

In this study, a new class of 4-amino-3-substituted-1, 2, 4-triazole-5-thiones (1–4) and their
corresponding condensed derivatives 3, 6-disubstituted 7H-1, 2, 4-triazolo [3, 4-b]-1, 3, 4 …

Newly designed triazolothiadiazines incorporating with structural motifs of nonsteroidal
analgesic anti-inflammatory drugs were synthesized and screened for their bioactivity …

Two series of 1, 2, 4-triazoles and 1, 2, 4-triazolo [3, 4-b]-1, 3, 4-thiadiazoles derived from
three selected arylpropionic acids namely, ibuprofen, flurbiprofen and naproxen, were …

In order to develop potent analgesic/anti-inflammatory compounds with reduced ulcerogenic
risk, a series of thiazolotriazolyl-carboxylic and acetic acid esters were synthesized and …

Previously, we demonstrated that certain heterocyclic compounds derived from 3‐
substituted‐1, 2, 4‐triazole‐5‐thiones had promising analgesic/anti‐inflammatory activities …