Bacterial toxins active against mosquitoes: Mode of action and resistance

MHNL Silva-Filha, TP Romão, TMT Rezende… - Toxins, 2021 - mdpi.com
Larvicides based on the bacteria Bacillus thuringiensis svar. israelensis (Bti) and
Lysinibacillus sphaericus are effective and environmentally safe compounds for the control …

[HTML][HTML] Mosquito-larvicidal Binary (BinA/B) proteins for mosquito control programs—advancements, challenges, and possibilities

M Sharma, V Kumar - Current Research in Insect Science, 2022 - Elsevier
The increasing global burden of mosquito-borne diseases require targeted, environmentally
friendly, and sustainable approaches for effective vector control without endangering the …

Culex quinquefasciatus alpha-glucosidase serves as a putative receptor of the Cry48Aa toxin from Lysinibacillus sphaericus

Q Guo, Y Gao, C Xing, Y Niu, L Ding, X Dai - Insect Biochemistry and …, 2022 - Elsevier
Abstract The Cry48Aa/Cry49Aa toxin of Lysinibacillus sphaericus shows specific toxicity
towards larvae of Culex spp. Individual Cry48Aa and Cry49Aa subunits interact with distinct …

Crystal structure of BinAB toxin receptor (Cqm1) protein and molecular dynamics simulations reveal the role of unique Ca (II) ion

M Sharma, V Kumar - International journal of biological macromolecules, 2019 - Elsevier
Abstract Glycoside hydrolase 13 (GH13) family represents a large and diverse enzyme
family. Cqm1, an amylomaltase of Culex mosquito, belongs to the GH13 family and …

Molecular and biological features of Culex quinquefasciatus homozygous larvae for two cqm1 alleles that confer resistance to Lysinibacillus sphaericus larvicides

HSG Menezes, NA Nascimento… - Pest Management …, 2021 - Wiley Online Library
BACKGROUND Culex quinquefasciatus resistance to the binary toxin from Lysinibacillus
sphaericus larvicides can occur because of mutations in the cqm1 gene that prevents the …

Using Smoke Condensed Liquids from Pruned Fruit-Tree Branches for Aedes Mosquito Larva Control

DS Yang, MW Shen, ST Chen - Agriculture, 2022 - mdpi.com
Some mosquitos are disease-causing vectors. Their widespread existence poses a great
threat to disease control worldwide. Finding an effective, low-cost solution for mosquito …

Liposome-based study provides insight into cellular internalization mechanism of mosquito-larvicidal BinAB toxin

M Sharma, A Kumar, V Kumar - The Journal of Membrane Biology, 2020 - Springer
Glycosylphosphatidylinositols (GPIs) anchored proteins are commonly localized onto lipid
rafts. These extracellular proteins participate in a variety of cellular functions, including as …

Mosquito-larvicidal BinA toxin displays affinity for glycoconjugates: Proposal for BinA mediated cytotoxicity

M Sharma, GD Gupta, V Kumar - Journal of invertebrate pathology, 2018 - Elsevier
Lysinibacillus sphaericus parasporal BinAB toxin displays mosquito larvicidal activity
against Culex and Anopheles, but several Aedes species are refractory. Recently reported …

Mosquito-larvicidal binary toxin receptor protein (Cqm1): crystallization and X-ray crystallographic analysis

M Sharma, A Lakshmi, GD Gupta… - … Section F: Structural …, 2018 - journals.iucr.org
Cqm1 from Culex quinquefasciatus has been identified as the receptor for Lysinibacillus
sphaericus binary toxin (BinAB). It is an amylomaltase that is presented on the epithelial …

The Cry48Aa N-terminal Domain is Responsible for Cry48Aa–Cry49Aa Interaction in Lysinibacillus sphaericus Toxin

Q Guo, Y Gao, C Xing, L Ding, X Dai, Q Xie, X Tan - Current microbiology, 2020 - Springer
Abstract The Cry48Aa/Cry49Aa binary toxin from Lysinibacillus sphaericus is composed of a
three-domain Cry-like toxin (Cry48Aa) and a binary-like protein (Cry49Aa) that work together …