Obesity and type 2 diabetes have both been associated with increased cancer risk and are
becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and …

Obesity-related breast cancer is an important threat that affects especially post-menopausal
women. The link between obesity and breast cancer seems to be relying on the …

Epithelial–mesenchymal transition (EMT) has been implicated in various aspects of tumor
development, including tumor invasion and metastasis, cancer stemness, and therapy …

Ovarian cancers represent the deadliest among gynecologic malignancies and are
characterized by a hierarchical structure with cancer stem cells (CSCs) endowed with self …

Tumor metastasis involves a series of biological steps during which the tumor cells acquire
the ability to invade surrounding tissues and survive outside the original tumor site. During …

The escalating epidemic of overweight and obesity is currently recognized as one of the
most significant health and economic concern worldwide. At the present time, over 1.9 billion …

Transmission and secretion of signals via the choroid plexus (ChP) brain barrier can
modulate brain states via regulation of cerebrospinal fluid (CSF) composition. Here, we …

Alzheimer's disease (AD) is characterized by the formation of senile plaques and
neurofibrillary tangles composed of phosphorylated Tau. Several findings suggest that …

The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in
obesity compared to its functions in the normal healthy state. In obese individuals, elevated …

Chronic inflammation is a highly prevalent consequence of changes in environmental and
lifestyle factors that contribute to the development of cancer. The basis for this critical …