The potential immunological mechanisms of sepsis

X Zhang, Y Zhang, S Yuan, J Zhang - Frontiers in immunology, 2024 - frontiersin.org
Sepsis is described as a life-threatening organ dysfunction and a heterogeneous syndrome
that is a leading cause of morbidity and mortality in intensive care settings. Severe sepsis …

A call for artificial intelligence implementation science centers to evaluate clinical effectiveness

CA Longhurst, K Singh, A Chopra, A Atreja… - NEJM AI, 2024 - ai.nejm.org
Artificial intelligence (AI) holds significant promise for revolutionizing health care by
enhancing diagnosis, treatment, and patients' safety. However, the current disparity between …

Integrating artificial intelligence into healthcare systems: more than just the algorithm

JCC Kwong, GC Nickel, SCY Wang, JC Kvedar - npj Digital Medicine, 2024 - nature.com
Boussina et al. recently evaluated a deep learning sepsis prediction model (COMPOSER) in
a prospective before-and-after quasi-experimental study within two emergency departments …

Use of artificial intelligence in critical care: opportunities and obstacles

MR Pinsky, A Bedoya, A Bihorac, L Celi, M Churpek… - Critical Care, 2024 - Springer
Background Perhaps nowhere else in the healthcare system than in the intensive care unit
environment are the challenges to create useful models with direct time-critical clinical …

(STRokE DOC-AI): Leveraging AI Tools to Optimize Both Hub and Spoke in a Telestroke Network

BC Meyer, DM Meyer, E St. Germain, N Pham… - NEJM AI …, 2024 - ai.nejm.org
Telestroke has become commonplace for hospitals requiring access to stroke expertise
when that expertise is not locally available. Telestroke networks have been developed to …

An optimal antibiotic selection framework for Sepsis patients using Artificial Intelligence

P Wendland, C Schenkel-Häger, I Wenningmann… - npj Digital …, 2024 - nature.com
In this work we present OptAB, the first completely data-driven online-updateable antibiotic
selection model based on Artificial Intelligence for Sepsis patients accounting for side …

Development and validation of a deep learning algorithm for the prediction of serum creatinine in critically ill patients

G Ghanbari, JY Lam, SP Shashikumar, L Awdishu… - JAMIA …, 2024 - academic.oup.com
Abstract Objectives Serum creatinine (SCr) is the primary biomarker for assessing kidney
function; however, it may lag behind true kidney function, especially in instances of acute …

Stronger Baseline Models--A Key Requirement for Aligning Machine Learning Research with Clinical Utility

N Wolfrath, J Wolfrath, H Hu, A Banerjee… - arXiv preprint arXiv …, 2024 - arxiv.org
Machine Learning (ML) research has increased substantially in recent years, due to the
success of predictive modeling across diverse application domains. However, well-known …

A Prospective Comparison of Large Language Models for Early Prediction of Sepsis

SP Shashikumar, S Nemati - Biocomputing 2025: Proceedings of …, 2024 - World Scientific
We present a comparative study on the performance of two popular open-source large
language models for early prediction of sepsis: Llama-3 8B and Mixtral 8x7B. The primary …

[HTML][HTML] Artificial Intelligence in Sepsis Management: An Overview for Clinicians

EG Bignami, M Berdini, M Panizzi… - Journal of Clinical …, 2025 - mdpi.com
Sepsis is one of the leading causes of mortality in hospital settings, and early diagnosis is a
crucial challenge to improve clinical outcomes. Artificial intelligence (AI) is emerging as a …