Preeclampsia: pathogenesis, prevention, and long-term complications

B Jim, SA Karumanchi - Seminars in nephrology, 2017 - Elsevier
Preeclampsia continues to afflict 5% to 8% of all pregnancies throughout the world and is
associated with significant morbidity and mortality to the mother and the fetus. Although the …

Matrix metalloproteinases in normal pregnancy and preeclampsia

J Chen, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Normal pregnancy is associated with marked hemodynamic and uterine changes that allow
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …

Mechanisms of endothelial dysfunction in hypertensive pregnancy and preeclampsia

JS Possomato-Vieira, RA Khalil - Advances in pharmacology, 2016 - Elsevier
Preeclampsia is a pregnancy-related disorder characterized by hypertension and could lead
to maternal and fetal morbidity and mortality. Although the causative factors and …

Maternal serum cytokine concentrations in healthy pregnancy and preeclampsia

T Spence, PJ Allsopp, AJ Yeates… - Journal of …, 2021 - Wiley Online Library
The maternal immune response is essential for successful pregnancy, promoting immune
tolerance to the fetus while maintaining innate and adaptive immunity. Uncontrolled …

Dysregulation of hydrogen sulfide producing enzyme cystathionine γ-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia

K Wang, S Ahmad, M Cai, J Rennie, T Fujisawa… - Circulation, 2013 - Am Heart Assoc
Background—The exact etiology of preeclampsia is unknown, but there is growing evidence
of an imbalance in angiogenic growth factors and abnormal placentation. Hydrogen sulfide …

Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia

IA Buhimschi, UA Nayeri, G Zhao, LL Shook… - Science translational …, 2014 - science.org
Preeclampsia is a pregnancy-specific disorder of unknown etiology and a leading
contributor to maternal and perinatal morbidity and mortality worldwide. Because there is no …

NLRP3 activation and its relationship to endothelial dysfunction and oxidative stress: implications for preeclampsia and pharmacological interventions

PR Nunes, SV Mattioli, VC Sandrim - Cells, 2021 - mdpi.com
Preeclampsia (PE) is a specific syndrome of human pregnancy, being one of the main
causes of maternal death. Persistent inflammation in the endothelium stimulates the …

Evidence-based revised view of the pathophysiology of preeclampsia

A Ahmed, H Rezai, S Broadway-Stringer - Hypertension: from basic …, 2017 - Springer
Preeclampsia is a life-threatening vascular disorder of pregnancy due to a failing stressed
placenta. Millions of women risk death to give birth each year and globally each year, almost …

Predictive role of neutrophil-to-lymphocyte ratio in preeclampsia: A meta-analysis including 3982 patients

Q Kang, W Li, N Yu, L Fan, Y Zhang, M Sha, J Xiao… - Pregnancy …, 2020 - Elsevier
Objective The predictive role of neutrophil-to-lymphocyte ratio (NLR) for preeclampsia (PE)
has been explored in several studies and current evidence seems to be conflicting. The aim …

Angiogenic and antiangiogenic factors in preeclampsia

FR Helmo, AMM Lopes, ACDM Carneiro… - … -Research and Practice, 2018 - Elsevier
Background Pre-eclampsia is a multifactorial hypertensive disorder that is triggered by
placental insufficiency and that accounts for up to 15% of maternal deaths. In normal …