MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis

EF Morand, M Leech, J Bernhagen - Nature reviews Drug discovery, 2006 - nature.com
Macrophage migration inhibitory factor (MIF) is well established as a key cytokine in immuno-
inflammatory diseases such as rheumatoid arthritis. Inflammation is now also recognized as …

CD74: an emerging opportunity as a therapeutic target in cancer and autoimmune disease

F Borghese, FIL Clanchy - Expert opinion on therapeutic targets, 2011 - Taylor & Francis
Introduction: CD74, also known as the invariant chain, participates in several key processes
of the immune system, including antigen presentation, B-cell differentiation and inflammatory …

MIF signal transduction initiated by binding to CD74

L Leng, CN Metz, Y Fang, J Xu, S Donnelly… - The Journal of …, 2003 - rupress.org
Macrophage migration inhibitory factor (MIF) accounts for one of the first cytokine activities to
have been described, and it has emerged recently to be an important regulator of innate and …

[HTML][HTML] Blockade of MIF–CD74 signalling on macrophages and dendritic cells restores the antitumour immune response against metastatic melanoma

CR Figueiredo, RA Azevedo, S Mousdell… - Frontiers in …, 2018 - frontiersin.org
Mounting an effective immune response against cancer requires the activation of innate and
adaptive immune cells. Metastatic melanoma is the most aggressive form of skin cancer …

NMR spectroscopy: a multifaceted approach to macromolecular structure

AE Ferentz, G Wagner - Quarterly reviews of biophysics, 2000 - cambridge.org
1. Introduction 292. Landmarks in NMR of macromolecules 322.1 Protein structures and
methods development 322.1. 1 Sequential assignment method 322.1. 2 Triple-resonance …

[HTML][HTML] Multiple roles of the invariant chain in MHC class II function

P Stumptner-Cuvelette, P Benaroch - Biochimica et Biophysica Acta (BBA) …, 2002 - Elsevier
Major histocompatibility complex class II molecules (MHC II) have developed a particular
trafficking pathway, which allows them to load antigenic peptides generated in the …

MIF, a controversial cytokine: a review of structural features, challenges, and opportunities for drug development

J Bloom, S Sun, Y Al-Abed - Expert opinion on therapeutic targets, 2016 - Taylor & Francis
Introduction: Macrophage migration inhibitory factor (MIF) has emerged as a promising drug
target in diseases including sepsis, rheumatoid arthritis, and cancer. MIF has multiple …

[HTML][HTML] An analysis of MIF structural features that control functional activation of CD74

G Pantouris, MA Syed, C Fan, D Rajasekaran… - Chemistry & biology, 2015 - cell.com
For more than 15 years, the tautomerase active site of macrophage migration inhibitory
factor (MIF) and its catalytic residue Pro1 have been being targeted for the development of …

The spectrum of HLA-DQ and HLA-DR alleles, 2006: a listing correlating sequence and structure with function

GP Bondinas, AK Moustakas, GK Papadopoulos - Immunogenetics, 2007 - Springer
The list of alleles in the HLA-DRB, HLA-DQA, and HLA-DQB gene loci has grown
enormously since the last listing in this journal 8 years ago. Crystal structure determination …

[图书][B] Handbook of cell-penetrating peptides

U Langel - 2006 - taylorfrancis.com
Since the first Handbook of Cell-Penetrating Peptides was prepared in 2001, the wealth of
new information on the use of these peptides as transport systems has in fact served to …