The cuprizone model: dos and do nots
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system. Various pre-clinical models with different specific features of the disease …
nervous system. Various pre-clinical models with different specific features of the disease …
Neurotoxic agent-induced injury in neurodegenerative disease model: Focus on involvement of glutamate receptors
Glutamate receptors play a crucial role in the central nervous system and are implicated in
different brain disorders. They play a significant role in the pathogenesis of …
different brain disorders. They play a significant role in the pathogenesis of …
Nrf2 deficiency increases oligodendrocyte loss, demyelination, neuroinflammation and axonal damage in an MS animal model
A Nellessen, S Nyamoya, A Zendedel, A Slowik… - Metabolic Brain …, 2020 - Springer
Oxidative stress is a pathophysiological hallmark of many CNS diseases, among multiple
sclerosis (MS). Accordingly, boosting the astrocytic transcription factor nuclear factor E2 …
sclerosis (MS). Accordingly, boosting the astrocytic transcription factor nuclear factor E2 …
Calorie restriction promotes remyelination in a Cuprizone-Induced demyelination mouse model of multiple sclerosis
Over the past few decades several attempts have been made to introduce a potential and
promising therapy for Multiple sclerosis (MS). Calorie restriction (CR) is a dietary …
promising therapy for Multiple sclerosis (MS). Calorie restriction (CR) is a dietary …
Coenzyme Q10 enhances remyelination and regulate inflammation effects of cuprizone in corpus callosum of chronic model of multiple sclerosis
Multiple Sclerosis (MS) is a chronic, progressive demyelinating disease of the central
nervous system that causes the most disability in young people, besides trauma. Coenzyme …
nervous system that causes the most disability in young people, besides trauma. Coenzyme …
Untargeted metabolomic profiling of cuprizone‐induced demyelination in mouse corpus callosum by UPLC‐orbitrap/MS reveals potential metabolic biomarkers of …
Z Zhao, T Li, X Dong, X Wang, Z Zhang… - Oxidative medicine …, 2021 - Wiley Online Library
Multiple sclerosis (MS) is a neurodegenerative disorder characterized by periodic neuronal
demyelination, which leads to a range of symptoms and eventually to disability. The goal of …
demyelination, which leads to a range of symptoms and eventually to disability. The goal of …
TRPV2: a key player in myelination disorders of the central nervous system
Transient potential receptor vanilloid 2 (TRPV2) is widely expressed through the nervous
system and specifically found in neuronal subpopulations and some glial cells. TRPV2 is …
system and specifically found in neuronal subpopulations and some glial cells. TRPV2 is …
Combination effects of mesenchymal stem cells transplantation and anodal transcranial direct current stimulation on a cuprizone-induced mouse model of multiple …
Multiple sclerosis (MS) has no absolute treatment, and researchers are still exploring to
introduce promising therapy for MS. Transcranial direct current stimulation (tDCS), is a safe …
introduce promising therapy for MS. Transcranial direct current stimulation (tDCS), is a safe …
Microglial Neuroinflammation-Independent Reversal of Demyelination of Corpus Callosum by Arsenic in a Cuprizone-Induced Demyelinating Mouse Model
Demyelination is the loss of myelin in CNS, resulting in damaged myelin sheath. Oxidative
stress and neuroinflammation play a key role in inducing demyelinating diseases like MS; …
stress and neuroinflammation play a key role in inducing demyelinating diseases like MS; …
Ebselen alleviates white matter lesions and improves cognitive deficits by attenuating oxidative stress via Keap1/Nrf2 pathway in chronic cerebral hypoperfusion mice
F Dong, W Yan, Q Meng, X Song, B Cheng… - Behavioural Brain …, 2023 - Elsevier
Oxidative stress is crucial in cerebral white matter lesions (WMLs) induced by chronic
cerebral hypoperfusion. Therefore, ameliorating oxidative damage is considered to be a …
cerebral hypoperfusion. Therefore, ameliorating oxidative damage is considered to be a …