Complexity science and systems thinking are increasingly recognized as relevant
paradigms for studying systems where biology, psychology, and socioenvironmental factors …

Many heat transfer and fluid flow problems are multiscale in nature, and the multiscale
numerical methods are needed to solve the problems by considering the phenomena in all …

We argue that, despite the fact that the field of multiscale modelling and simulation has
enjoyed significant success within the past decade, it still holds many open questions that …

We expect that multiscale simulations will be one of the main high performance computing
workloads in the exascale era. We propose multiscale computing patterns as a generic …

We review a methodology to design, implement and execute multi-scale and multi-science
numerical simulations. We identify important ingredients of multi-scale modelling and give a …

Abstract We present the Multiscale Coupling Library and Environment: MUSCLE 2. This
multiscale component-based execution environment has a simple to use Java, C++, C …

In the last few decades, multiscale modelling has emerged as one of the dominant
modelling paradigms in many areas of science and engineering. Its rise to dominance is …

We present the VECMA toolkit (VECMAtk), a flexible software environment for single and
multiscale simulations that introduces directly applicable and reusable procedures for …

One of the greatest challenges in biomedicine is to get a unified view of observations made
from the molecular up to the organism scale. Towards this goal, multiscale models have …

Multiscale modelling and simulation typically entails coupling multiple simulation codes into
a single program. Doing this in an ad-hoc fashion tends to result in a tightly coupled, difficult …