Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction

Y Lu, FQ Bu, F Wang, L Liu, S Zhang, G Wang… - Translational …, 2023 - Springer
Physical exercise is of great significance for maintaining human health. Exercise can
provide varying degrees of benefits to cognitive function at all stages of life cycle. Currently …

Running from stress: neurobiological mechanisms of exercise-induced stress resilience

M Nowacka-Chmielewska, K Grabowska… - International journal of …, 2022 - mdpi.com
Chronic stress, even stress of a moderate intensity related to daily life, is widely
acknowledged to be a predisposing or precipitating factor in neuropsychiatric diseases …

Prolonged isolation stress accelerates the onset of Alzheimer's disease-related pathology in 5xFAD mice despite running wheels and environmental enrichment

JL Peterman, JD White, A Calcagno, C Hagen… - Behavioural Brain …, 2020 - Elsevier
Research has demonstrated that stress can exacerbate AD pathology in transgenic mouse
models of AD. The purpose of the present studies was to extend this work by determining …

Acute physical exercise improves recognition memory via locus coeruleus activation but not via ventral tegmental area activation

KR Lima, BHS das Neves, GS Carrazoni… - Physiology & …, 2023 - Elsevier
Both animals and humans have been studied to explore the impact of acute physical
exercise (PE) on memory. In rats, a single session of PE enhances the persistence of novel …

Exercise ameliorates anxious behavior and promotes neuroprotection through osteocalcin in VCD‐induced menopausal mice

Y Kang, J Yao, X Gao, H Zhong, Y Song… - CNS Neuroscience …, 2023 - Wiley Online Library
Aims As the ovaries age and women transition to menopause and postmenopause, reduced
estradiol levels are associated with anxiety and depression. Exercise contributes to alleviate …

Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory

SS Lander, S Chornyy, H Safory… - Genes, Brain and …, 2020 - Wiley Online Library
Abstract Glutamate Dehydrogenase 1 (GDH), encoded by the Glud1 gene in rodents, is a
mitochondrial enzyme critical for maintaining glutamate homeostasis at the tripartite …

Acute physical exercise prevents memory amnesia caused by protein synthesis inhibition in rats' hippocampus

KR Lima, BHS das Neves, GJ Sigaran… - Neurochemistry …, 2024 - Elsevier
The benefits of physical exercise (PE) on memory consolidation have been well-
documented in both healthy and memory-impaired animals. However, the underlying …

Temporal dynamics of brain BDNF expression following a single bout of exercise: a bioluminescence imaging study

T Inoue, R Ikegami, Y Takamatsu, M Fukuchi… - Neuroscience …, 2023 - Elsevier
Physical exercise increases brain-derived neurotrophic factor (BDNF) expression in the
brain. However, the absence of non-invasive and repetitive monitoring of BDNF expression …

Effects of treadmill running on anxiety-and craniofacial pain-like behaviors with histone H3 acetylation in the brain of mice subjected to social defeat stress

K Piriyaprasath, M Hasegawa, Y Iwamoto… - PloS one, 2025 - journals.plos.org
This study examined the effects of treadmill running (TR) regimens on craniofacial pain-and
anxiety-like behaviors, as well as their effects on neural changes in specific brain regions of …

[HTML][HTML] Exercise-induced anxiety impairs local and systemic inflammatory response and glucose metabolism in C57BL/6J mice

I Gálvez, MC Navarro, S Torres-Piles… - Brain, Behavior, & …, 2025 - Elsevier
Introduction The complex physiological and psychological responses to regular exercise are
yet to be fully elucidated. Exercise strongly modulates the immune system, inducing a …