A goal of structural biology is to understand how macromolecules carry out their biological
roles by identifying their metastable states, mechanisms of action, pathways leading to …

The structures of macromolecular assemblies have given us deep insights into cellular
processes and have profoundly impacted biological research and drug discovery. We …

Stimulated by informal conversations at the XVII International Small Angle Scattering (SAS)
conference (Traverse City, 2017), an international team of experts undertook a round-robin …

By providing predicted protein structures from nearly all known protein sequences, the
artificial intelligence program AlphaFold (AF) is having a major impact on structural biology …

Biological macromolecules in solution are surrounded by a hydration shell, whose structure
differs from the structure of bulk solvent. While the importance of the hydration shell for …

Described here is the current status of the upgraded in situ size-exclusion chromatography
(SEC) system implemented with the D22 small-angle neutron scattering (SANS) instrument …

In 2017, guidelines were published for reporting structural modelling of small-angle
scattering (SAS) data from biomolecules in solution that exemplified best-practice …

Single-chain polymer nanoparticles (SCNPs) combine the chemical diversity of synthetic
polymers with the intricate structure of biopolymers, generating versatile biomimetic …

Measuring the compaction of a protein or complex is key to understand the interactions
within and between biomolecules. Experimentally, protein compaction is often probed either …

Enzymatic activity is heavily influenced by pH, but the rationale for the dynamical
mechanism of pH-dependent enzymatic activity has not been fully understood. In this work …