Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

While the microtubule-binding capacity of the protein tau has been known for many years,
new functions of tau in signaling and cytoskeletal organization have recently emerged. In …

This article is part of a Minifocus on Ubiquitin. For further reading, please see related
articles: ʻUbiquitin and SUMO in DNA repair at a glanceʼ by Helle D. Ulrich (J. Cell Sci …

Heat shock protein 70 (Hsp70a) is a molecular chaperone that is expressed in response to
stress. In this role, Hsp70 binds to its protein substrates and stabilize them against …

Gastrointestinal enterochromaffin cells regulate bone and gut homeostasis via serotonin (5-
hydroxytryptamine [5-HT]) production. A recent report suggested that gut microbes regulate …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

Heat shock cognate protein 70 (HSC70) is a constitutively expressed molecular chaperone
which belongs to the heat shock protein 70 (HSP70) family. HSC70 shares some of the …

The selectivity of the ubiquitin–26 S proteasome system (UPS) for a particular substrate
protein relies on the interaction between a ubiquitin-conjugating enzyme (E2, of which a cell …

The molecular chaperone Hsp90 (90 kDa heat-shock protein) is a remarkably versatile
protein involved in the stress response and in normal homoeostatic control mechanisms. It …

Tauopathies are neurodegenerative diseases, sporadic or familial, mainly characterized by
dementia and parkinsonism associated to atrophy of the frontotemporal cortex and the basal …