S Azwar, HF Seow, M Abdullah, M Faisal Jabar… - Biology, 2021 - mdpi.com
Simple Summary Acquired resistance to chemotherapy by cancer cells is the predominant factor in chemotherapy failure, which ultimately leads to disease progression and death …
G McInnes, A Lavertu, K Sangkuhl… - Clinical …, 2021 - Wiley Online Library
Pharmacogenetics (PGx) studies the influence of genetic variation on drug response. Clinically actionable associations inform guidelines created by the Clinical …
B Wörmann, C Bokemeyer, T Burmeister… - Oncology research and …, 2020 - karger.com
Background: 5-Fluorouracil (FU) is one of the most commonly used cytostatic drugs in the systemic treatment of cancer. Treatment with FU may cause severe or life-threatening side …
M Manchia, C Pisanu, A Squassina… - Pharmacogenomics …, 2020 - Taylor & Francis
Precision medicine is increasingly recognized as a promising approach to improve disease treatment, taking into consideration the individual clinical and biological characteristics …
EC Hulshof, MJ Deenen, M Nijenhuis… - European Journal of …, 2023 - nature.com
Abstract The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate PGx implementation by developing evidence-based pharmacogenetics guidelines to optimize …
Preemptive targeted pharmacogenetic testing of candidate variations in DPYD is currently being used to limit toxicity associated with fluoropyrimidines. The use of innovative next …
JE Knikman, H Gelderblom, JH Beijnen… - Clinical …, 2021 - Wiley Online Library
Fluoropyrimidines are widely used in the treatment of several types of solid tumors. Although most often well tolerated, severe toxicity is encountered in~ 20–30% of the patients …
Simple Summary 5-Fluorouracil (5-FU) is a chemotherapy drug that is commonly used to treat multiple cancers. Many people who are treated with 5-FU experience severe toxicity to …
P García-Alfonso, M Saiz-Rodríguez… - Clinical and …, 2022 - Springer
Fluorouracil (5-FU) and oral fluoropyrimidines, such as capecitabine, are widely used in the treatment of cancer, especially gastrointestinal tumors and breast cancer, but their …