Peptidyl toxins are used extensively to determine the pharmacology of ion channels. Four
families of peptides have been purified from scorpion venom. In this article, the classification …

Large-conductance Ca2+-activated K+ channels facilitate the efflux of K+ ions from a variety
of cells and tissues following channel activation. It is now recognized that BK channels …

The detection of organic molecules is important in many areas, including medicine,
environmental monitoring and defence 1, 5. Stochastic sensing is an approach that relies on …

The high sensitivity of voltage-gated ion channels to changes in membrane potential implies
that the process of channel opening is accompanied by large charge movements. Previous …

Molecular toxinology research was initially driven by an interest in the small subset of animal
toxins that are lethal to humans. However, the realization that many venomous creatures …

A novel peptidyl inhibitor of K+ channels has been purified to homogeneity from venom of
the new world scorpion Centruroides margaritatus. The primary structure of this 39-amino …

Iberiotoxin, a toxin purified from the scorpion Buthus tamulus is a 37 amino acid peptide
having 68% homology with charybdotoxin. Charybdotoxin blocks large conductance Ca (2+) …

Revised Manuscript Received April 1, 19949 abstract: Three new toxins from the venom of
the scorpion Leiurus quinquestriatus var. hebraeus have been identified on the basis of their …

Summary The Kv2. 1 voltage-activated K ũ channel, a Shab-related K ũ channel isolated
from rat brain, is insensitive to previously identified peptide inhibitors. We have isolated two …

For many years, neuronal K'channels were pharmacological orphans, essential membrane
proteins against which'no natural toxins were known. While biochemically and …