The Wnt/β-catenin signaling pathway has been implicated as the central mechanism that
drives colorectal carcinogenesis. Its activation is historically due to mutation on APC …

Tankyrases are multifunctional poly (adenosine diphosphate-ribose) polymerases that
regulate diverse biological processes including telomere maintenance and cellular …

Autologous epidermal cultures restore a functional epidermis on burned patients.
Transgenic epidermal grafts do so also in genetic skin diseases such as Junctional …

Background Aberrant WNT/β-catenin signaling drives carcinogenesis. Tankyrases poly
(ADP-ribosyl) ate and destabilize AXINs, β-catenin repressors. Tankyrase inhibitors block …

Drug resistance is a leading cause for the failure of cancer treatments. Plasticity of cancer
cells to acquire stem cell-like properties enables them to escape drug toxicity through …

Abstract Background The Hippo signaling pathway is an evolutionarily conserved signaling
module that controls organ size in different species, and the disorder of the Hippo pathway …

Evidence suggests that the growth and therapeutic resistance of glioblastoma (GBM) may be
enabled by a population of glioma stem cells (GSCs) that are regulated by typical stem cell …

Aniridia is a panocular condition characterized by impaired eye development and vision,
which is mainly due to the haploinsufficiency of the paired-box-6 (PAX6) gene. Like what is …

TNKS is a new target for the treatment of lung adenocarcinoma, the synergistic effects of the
TCM compound Xiaoyan decoction and the TNKS inhibitor E7449 in the intervention on …

Cancer stem cells (CSCs) are a tumor cell subpopulation that drives tumor progression and
metastasis, leading to a poor overall survival of patients. In colorectal cancer (CRC), the …