IL-10 is an anti-inflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK
cells, and macrophages, all of which are required for optimal pathogen clearance but also …

Malaria is a significant public health problem in more than 100 countries and causes an
estimated 200 million new infections every year. Despite the significant effort to eradicate …

Greater than 80% of malaria-related mortality occurs in sub-Saharan Africa due to infections
with Plasmodium falciparum. The majority of P. falciparum-related mortality occurs in …

IL-10 produced by CD4+ T cells suppresses inflammation by inhibiting T cell functions and
the upstream activities of antigen presenting cells (APCs). IL-10 was first identified in Th2 …

Malaria is a major world health problem. It results from infection of parasites belonging to the
genus Plasmodium. Plasmodium falciparum and Plasmodium vivax cause the major human …

There is considerable debate as to the nature of the primary parasite-derived moieties that
activate innate pro-inflammatory responses during malaria infection. Microparticles (MPs) …

Malaria is a deadly infectious disease caused by the intraerythrocytic protozoan parasite
Plasmodium. The four species of Plasmodium known to affect humans all produce an …

Although whole-parasite vaccine strategies for malaria infection have regained attention,
their immunological mechanisms of action remain unclear. We find that immunization of …

Abstract The interleukin (IL)-1 family member IL-37 is one of few anti-inflammatory cytokines,
and it is capable of countering a broad spectrum of proinflammatory assaults. Although it is …

Plasmodium falciparum malaria is one of the leading global causes of morbidity and
mortality with African children bearing the highest disease burden. Among the various …