Proton-pump inhibitors (PPIs) are the most effective therapy for the full spectrum of gastric-
acid-related diseases. However, in the past decade, a steadily increasing list of …

Proton-pump inhibitors (PPIs) are a widely prescribed class of medications used to treat acid-
related disorders and use has significantly increased over the last few decades. PPIs are …

Objective: To develop a North American Society for Pediatric Gastroenterology, Hepatology,
and Nutrition (NASPGHAN) and European Society for Pediatric Gastroenterology …

Immune checkpoint inhibitors that target the programmed death 1 (PD-1) signaling pathway
have recently been approved for use in advanced pretreated non–small cell lung cancer …

Background Acute interstitial nephritis (AIN) is an important cause of acute kidney injury,
especially in hospitalized patients. The cause and outcome of AIN, particularly that due to …

Proton pump inhibitors (PPIs) have been increasingly used over the last decades and there
are concerns about overuse and the numerous reported side-effects. It is uncertain whether …

Drugs are a common source of acute kidney injury. Compared with 30 years ago, the
average patient today is older, has more comorbidities, and is exposed to more diagnostic …

Acute interstitial nephritis (AIN) is a common cause of acute kidney injury. Many etiologies of
AIN have been recognized—including allergic/drug-induced, infectious …

Background Proton pump inhibitors (PPIs) cause interstitial nephritis and are an
underappreciated cause of acute kidney injury. We examined the risk of acute kidney injury …

The magnitude of the suspected increase in risk of acute interstitial nephritis among proton
pump inhibitor users is uncertain. Here, we conducted a nested case-control study using …