For many decades, the design of new nucleoside analogs as potential therapeutic agents
focused on both sugar and nucleobase modifications. These nucleoside analogs rely on …

A substantial portion of metabolism involves transformation of phosphate esters, including
pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and …

A series of seventeen hitherto unknown ANP analogs bearing the (E)-but-2-enyl aliphatic
side chain and modified heterocyclic base such as cytosine and 5-fluorocytosine, 2 …

Several hitherto unknown (E)-but-2-enyl nucleoside phosphonoamidate analogs (ANPs)
were prepared directed with nitrogen reagents by cross-metathesis in water-under …

The synthesis of new class of potential TPase inhibitors containing a
difluoromethylphosphonate function as phosphate mimic is reported. This new series was …

Phosphazene chemistry continues to expand in its breadth and application. This article
discusses new research published in 2013 covering mono-and dimeric structures …

Abstract Flavin-Dependent Thymidylate Synthase (FDTS) encoded by ThyX gene was
discovered as a new class of thymidylate synthase involved in the de novo synthesis of …

The synthesis of fluoroaminosulfones derived from piperidine and nucleic bases followed by
the study of their chemical behavior in the modified Julia reaction are described. The …

Mutations in the human PANK2 gene are implicated in neurodegenerative diseases such as
pantothenate kinase-associated neurodegeneration (PKAN) and result in low levels of …

Seventeen hitherto unknown bis (POM) prodrugs of novel (E)-[4′-phosphono-but-2′-en-
1′-yl] purine nucleosides were prepared in a straight approach and at good yields. Those …