The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

Colorectal cancer (CRC) is a public health problem. It is the third most common cancer in the
world, with nearly 1.8 million new cases diagnosed in 2018. The only curative treatment is …

Cancer cells employ both conventional oxidative metabolism and glycolytic anaerobic
metabolism. However, their proliferation is marked by a shift towards increasing glycolytic …

Hypoxia occurs frequently in human cancers and induces adaptive changes in cell
metabolism that include a switch from oxidative phosphorylation to glycolysis, increased …

Emerging evidence indicates that cancer is primarily a metabolic disease involving
disturbances in energy production through respiration and fermentation. The genomic …

Emerging evidence indicates that impaired cellular energy metabolism is the defining
characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal …

Alterations in cellular metabolism are among the most consistent hallmarks of cancer.
Herein we have investigated the relationship between increased aerobic lactate production …

Defective or inefficient apoptosis is an acquired hallmark of cancer cells. Thus, a thorough
understanding of apoptotic signaling pathways and insights into apoptosis resistance …

Cell proliferation only proceeds when metabolism is capable of providing a budget of
metabolic intermediates that is adequate to ensure both energy regeneration and the …

A considerable amount of knowledge has been produced during the last five years on the
bioenergetics of cancer cells, leading to a better understanding of the regulation of energy …