The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …

Rho-associated kinases ROCK1 and ROCK2 are key regulators of actin cytoskeleton
dynamics downstream of Rho GTPases that participate in the control of important …

Cell migration initiates by traction generation through reciprocal actomyosin tension and
focal adhesion reinforcement, but continued motility requires adaptive cytoskeletal …

Hypertensive cardiac remodeling is characterized by left ventricular hypertrophy and
interstitial fibrosis, which can lead to heart failure with preserved ejection fraction. The Rho …

Abstract Acetyl-coA carboxylase 1 (ACC1) is the first and rate-limiting enzyme in the de novo
fatty acid synthesis (FASyn) pathway. In this study, through public database analysis and …

The regulation of muscle contraction is a critical function in the cardiovascular system, and
abnormalities may be life-threatening or cause illness. The common basic mechanism in …

Smooth muscle is a central structure involved in the regulation of airway tone. In addition, it
plays an important role in the development of some pathologies generated by alterations in …

Cerebral small vessel disease (CSVD) is the most common progressive vascular disease
that causes vascular dementia. Aging and hypertension are major contributors to CSVD, but …

An increase in intracellular Ca 2+ is the primary trigger of contraction of gastrointestinal (GI)
smooth muscles. However, increasing the Ca 2+ sensitivity of the myofilaments by elevating …

A hallmark of smooth muscle cells is their ability to adapt their functions to meet temporal
and chronic fluctuations in their demands. These functions include force development and …