[HTML][HTML] Sympathetic nervous system activation and heart failure: Current state of evidence and the pathophysiology in the light of novel biomarkers

JA Borovac, D D'Amario, J Bozic… - World journal of …, 2020 - ncbi.nlm.nih.gov
Heart failure (HF) is a complex clinical syndrome characterized by the activation of at least
several neurohumoral pathways that have a common role in maintaining cardiac output and …

[HTML][HTML] Heart failure as an autonomic nervous system dysfunction

T Kishi - Journal of cardiology, 2012 - Elsevier
In heart failure, it has been recognized that the sympathetic nervous system (SNS) is
activated and the imbalance of the activity of the SNS and vagal activity interaction occurs …

The sympathetic nervous system and heart failure

DY Zhang, AS Anderson - Cardiology clinics, 2014 - cardiology.theclinics.com
Heart failure (HF) is a syndrome characterized by upregulation of the sympathetic nervous
system and abnormal responsiveness of the parasympathetic nervous system. 1 Evidence …

Role of comorbidities in heart failure prognosis Part 2: Chronic kidney disease, elevated serum uric acid

A Tedeschi, P Agostoni, B Pezzuto… - European journal of …, 2020 - journals.sagepub.com
Despite improvements in pharmacotherapy, morbidity and mortality rates in community-
based populations with chronic heart failure still remain high. The increase in medical …

Importance of rostral ventrolateral medulla neurons in determining efferent sympathetic nerve activity and blood pressure

H Kumagai, N Oshima, T Matsuura, K Iigaya… - Hypertension …, 2012 - nature.com
Accentuated sympathetic nerve activity (SNA) is a risk factor for cardiovascular events. In this
review, we investigate our working hypothesis that potentiated activity of neurons in the …

Brain-selective overexpression of human angiotensin-converting enzyme type 2 attenuates neurogenic hypertension

Y Feng, H Xia, Y Cai, CM Halabi, LK Becker… - Circulation …, 2010 - Am Heart Assoc
Rationale: Angiotensin converting enzyme type 2 (ACE2) is a new member of the brain renin-
angiotensin system, that might be activated by an overactive renin-angiotensin system …

Angiotensin II receptors and drug discovery in cardiovascular disease

C Dasgupta, L Zhang - Drug discovery today, 2011 - Elsevier
Hypertension is one of the cardiovascular diseases that might cause cardiovascular
remodeling and endothelial dysfunction besides high blood pressure. Angiotensin II (Ang II) …

Chronic intermittent hypoxia augments chemoreflex control of sympathetic activity: role of the angiotensin II type 1 receptor

NJ Marcus, YL Li, CE Bird, HD Schultz… - Respiratory physiology & …, 2010 - Elsevier
Chronic exposure to intermittent hypoxia (CIH) increases carotid sinus nerve activity in
normoxia and in response to acute hypoxia. We hypothesized that CIH augments basal and …

Role of exercise training on autonomic changes and inflammatory profile induced by myocardial infarction

B Rodrigues, FS Lira… - Mediators of …, 2014 - Wiley Online Library
The cardiovascular autonomic imbalance in patients after myocardial infarction (MI) provides
a significant increase in mortality rate, and seems to precede metabolic, hormonal, and …

Angiotensin II regulation of angiotensin‐converting enzymes in spontaneously hypertensive rat primary astrocyte cultures

YV Gowrisankar, MA Clark - Journal of neurochemistry, 2016 - Wiley Online Library
Angiotensin (Ang) II plays a critical role in cardiovascular and blood pressure regulation.
Ang II is produced by angiotensin‐converting enzyme (ACE) and it interacts with the Ang AT …