This review critically summarizes the neuropathology and genetics of schizophrenia, the
relationship between them, and speculates on their functional convergence. The …

The kynurenine pathway of tryptophan degradation generates several neuroactive
compounds. Of those, kynurenic acid is an N-methyl-d-aspartate (NMDA) and alpha7 …

1. After 50 years of antipsychotic drug development focused on the dopamine D2 receptor,
schizophrenia remains a chronic, disabling disorder for most affected individuals. 2. Studies …

Schizophrenia is a serious mental disorder that affects up to 1% of the population worldwide.
As of yet, neurochemical mechanisms underlying schizophrenia remain unknown. To date …

Much work has been done to identify susceptibility genes in schizophrenia and bipolar
disorder. Several well established linkages have emerged in schizophrenia. Strongly …

Methamphetamine (METH) is a frequent drug of abuse in US populations and commonly
associated with psychosis. This may be a factor in frequent criminal justice referrals and …

It has been conventional for psychiatric research, including the search for predisposing
genes, to proceed under the assumption that schizophrenia and bipolar disorder are …

Objective: The authors used a custom array of 1,536 single-nucleotide polymorphisms
(SNPs) to interrogate 94 functionally relevant candidate genes for schizophrenia and identify …

A subset of glutamate receptors that are specifically sensitive to the glutamate analog N-
methyl-D-aspartate (NMDA) are molecular coincidence detectors, necessary for activity …

Schizophrenia, schizoaffective disorder, and bipolar disorder are common psychiatric
disorders with high heritabilities and variable phenotypes. The Disrupted in Schizophrenia 1 …