The abilities to sense environmental and internal temperatures are required for survival,
both for maintenance of homeostasis and for avoidance of tissue-damaging noxious …

Abdominal pain is a common symptom of inflammatory bowel disease (IBD: Crohn's
disease, ulcerative colitis). Pain may arise from different mechanisms, which can include …

While acute inflammation is a natural physiological response to tissue injury or infection,
chronic inflammation is maladaptive and engenders a considerable amount of adverse pain …

BACKGROUND & AIMS: The neuropeptides calcitonin gene-related peptide (CGRP) and
substance P, and calcium channels, which control their release from extrinsic sensory …

Background & Aims: Robust chemical or mechanical irritation of the colon of neonatal rats
leads to chronic visceral hypersensitivity. The clinical and physiologic relevance of such …

This protocol details methods to identify and record from cutaneous primary afferent axons in
an isolated mammalian skin–saphenous nerve preparation. The method is based on …

The vanilloid receptor TRPV1 is now recognized as a molecular integrator of painful stimuli
ranging from noxious heat to endovanilloids in inflammation. Pharmacological blockade of …

purpose. The authors investigated the contributions of the transient receptor potential
vanilloid-1 receptor (TRPV1) and Ca 2+ to microglial IL-6 and nuclear factor kappa B (NFκB) …

α-Calcitonin gene-related peptide (αCGRP) is a neuropeptide that is expressed in motor and
sensory neurons. It is a powerful vasodilator and has been implicated in diverse metabolic …

Aminoglycoside antibiotics such as gentamicin and amikacin are well recognized as a
clinically important antibiotic class because of their reliable efficacy and low cost. However …