NK cells are the major lymphocyte subset of the innate immune system that mediates
antiviral and anti-tumor responses. It is well established that they develop mechanisms to …

CD3− CD56+ NK cells develop from CD34+ hematopoietic progenitors (HPCs) in vivo, and
this process can be recapitulated in vitro. The prevailing model is that human NK cell …

Summary The Thy-l. l “Sea-1 h'Lin-'l” population, representing 0.05% of C57BL/Ka-Thy-l. 1
bone marrow, is highly enriched for hematopoietic stem cells and includes all multipotent …

The ikaros gene encodes a family of early hematopoietic-and lymphocyte-restricted
transcription factors. Mice homorygous for a germline mutation in the lkaros DNA-binding …

The y subunit of immunoglobulin Fc receptors is an essential component of the high-affinity
receptor for IgE (FcERI) and the low-affinity receptor for IgG (FcyRIII) and is associated with …

For a brief period during fetal lymph node organogenesis in mice, lymph node postcapillary
high endothelial venules surprisingly express the Peyer's patch addressin MAdCAM-1. This …

Transcription factors with a basic helix–loop–helix (HLH) motif have been shown to be
crucial for various cell differentiation processes during development of multicellular …

Rationale The liver-specific natural killer (NK) cell population is critical for local innate
immune responses, but the mechanisms that lead to their selective homing and the …

The liver represents a frontline immune organ that is constantly exposed to a variety of gut-
derived antigens as a result of its unique location and blood supply. With a predominant role …

▪ Abstract Natural killer (NK) cells play important roles in immunological processes, including
early defense against viral infections. This review provides an overview of the dynamic in …