Gene–environment interactions have been traditionally understood to promote the
acquisition of mutations that drive multistage carcinogenesis, and, in the case of inherited …

Adequate maternal vascular adaptations and blood supply to the uterus and placenta are
crucial for optimal oxygen and nutrient transport to growing fetuses of eutherian mammals …

Evidence supporting an early origin of prostate cancer is growing. We demonstrated
previously that brief exposure of neonatal rats to estradiol or bisphenol A elevated their risk …

Elevated maternal testosterone levels are shown to cause fetal growth restriction, eventually
culminating in sex-specific adult-onset hypertension that is more pronounced in males than …

Hypertension has been linked with peripheral and central reductions in vascular density,
and with devastating effects on brain function. However, the underlying mechanisms in the …

The aim of this study was to measure umbilical blood androgen concentrations in a birth
cohort using a highly specific liquid chromatography-tandem mass spectrometry (LC …

Introduction: Blood pressure is lower in females than males. Angiotensin II type-2 receptor
(AT2R) induces vasodilation. This study determined whether sex differences in vascular …

Background Per-and polyfluoroalkyl substances (PFASs) are widely used in China, but little
is known about the association between prenatal PFASs exposure and fetal reproductive …

Accurately measuring hormone exposure during prenatal life presents a methodological
challenge and there is currently no “gold standard” approach. Ideally, circulating fetal …

Background Triclosan (TCS) has been widely detected in pregnant women. The
reproductive endocrine-disrupting effects of TCS have been observed in humans and …