Exosomes: Therapy delivery tools and biomarkers of diseases

L Barile, G Vassalli - Pharmacology & therapeutics, 2017 - Elsevier
Virtually all cells in the organism secrete extracellular vesicles (EVs), a heterogeneous
population of lipid bilayer membrane-enclosed vesicles that transport and deliver payloads …

The lipid composition of extracellular vesicles: applications in diagnostics and therapeutic delivery

S Ghadami, K Dellinger - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
Extracellular vesicles (EVs), including exosomes, with nanoscale sizes, biological origins,
various functions, and unique lipid and protein compositions have been introduced as …

Functional siRNA delivery by extracellular vesicle–liposome hybrid nanoparticles

MJW Evers, SI van de Wakker… - Advanced …, 2022 - Wiley Online Library
The therapeutic use of RNA interference is limited by the inability of siRNA molecules to
reach their site of action, the cytosol of target cells. Lipid nanoparticles, including liposomes …

Applying extracellular vesicles based therapeutics in clinical trials–an ISEV position paper

T Lener, M Gimona, L Aigner, V Börger… - Journal of …, 2015 - Taylor & Francis
Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different
cell types and participate in physiological and pathophysiological processes. EVs mediate …

Extracellular vesicles as drug delivery systems: lessons from the liposome field

R van der Meel, MHAM Fens, P Vader… - Journal of controlled …, 2014 - Elsevier
Extracellular vesicles (EVs) are membrane-derived particles surrounded by a (phospho)
lipid bilayer that are released by cells in the human body. In addition to direct cell-to-cell …

Focus on mesenchymal stem cell‐derived exosomes: opportunities and challenges in cell‐free therapy

L Cheng, K Zhang, S Wu, M Cui, T Xu - Stem cells international, 2017 - Wiley Online Library
Mesenchymal stem cells have been at the forefront of regenerative medicine for many years.
Exosomes, which are nanovesicles involved in intercellular communication and the …

Therapeutic and diagnostic applications of extracellular vesicles

S Stremersch, SC De Smedt, K Raemdonck - Journal of Controlled Release, 2016 - Elsevier
During the past two decades, extracellular vesicles (EVs) have been identified as important
mediators of intercellular communication, enabling the functional transfer of bioactive …

[HTML][HTML] Extracellular vesicle-and extracellular vesicle mimetics-based drug delivery systems: new perspectives, challenges, and clinical developments

P Gangadaran, BC Ahn - Pharmaceutics, 2020 - mdpi.com
Extracellular vesicles (EVs) are small membrane-based nanovesicles naturally released
from cells. Extracellular vesicles mimetics (EVMs) are artificial vesicles engineered from …

Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs

S Stremersch, RE Vandenbroucke… - Journal of Controlled …, 2016 - Elsevier
Exosome-like vesicles (ELVs) play an important role in intercellular communication by acting
as natural carriers for biomolecule transfer between cells. This unique feature rationalizes …

The role of bone marrow mesenchymal stem cell derived extracellular vesicles (MSC-EVs) in normal and abnormal hematopoiesis and their therapeutic potential

AK Batsali, A Georgopoulou, I Mavroudi… - Journal of clinical …, 2020 - mdpi.com
Mesenchymal stem cells (MSCs) represent a heterogeneous cellular population responsible
for the support, maintenance, and regulation of normal hematopoietic stem cells (HSCs). In …