Tissue injury initiates a complex repair process, which in some organisms can lead to the
complete regeneration of a tissue. In mammals, however, the repair of most organs is …

The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling system
regulates a variety of biological processes, including embryogenesis, angiogenesis, wound …

Idiopathic pulmonary fibrosis is a common form of interstitial lung disease resulting in
alveolar remodeling and progressive loss of pulmonary function because of chronic alveolar …

The lung is morphologically structured into a complex tree-like network with branched
airways ending distally in a large number of alveoli for efficient oxygen exchange. At the …

Susceptibility to chronic obstructive pulmonary disease (COPD) beyond cigarette smoking is
incompletely understood, although several genetic variants associated with COPD are …

Primary defects in lung branching morphogenesis, resulting in neonatal lethal pulmonary
hypoplasias, are incompletely understood. To elucidate the pathogenetics of human lung …

Throughout life adult animals crucially depend on stem cell populations to maintain and
repair their tissues to ensure life-long organ function. Stem cells are characterized by their …

A genetic contribution to develop chronic obstructive pulmonary disease (COPD) is well
established. However, the specific genes responsible for enhanced risk or host differences …

The FGF family comprises 22 members with diverse functions in development and health.
FGF10 specifically activates FGFR2b in a paracrine manner with heparan sulfate as a co …

Fibroblast growth factor 10 (FGF10) plays an important role in mouse lung development,
injury, and repair. It is considered the main morphogen driving lung branching …