Cryo-EM in drug discovery: achievements, limitations and prospects
JP Renaud, A Chari, C Ciferri, W Liu… - Nature reviews Drug …, 2018 - nature.com
Cryo-electron microscopy (cryo-EM) of non-crystalline single particles is a biophysical
technique that can be used to determine the structure of biological macromolecules and …
technique that can be used to determine the structure of biological macromolecules and …
Determinants, maintenance, and function of organellar pH
SA Freeman, S Grinstein… - Physiological reviews, 2023 - journals.physiology.org
The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …
Cryo-EM structure of the entire mammalian F-type ATP synthase
G Pinke, L Zhou, LA Sazanov - Nature structural & molecular biology, 2020 - nature.com
The majority of adenosine triphosphate (ATP) powering cellular processes in eukaryotes is
produced by the mitochondrial F1Fo ATP synthase. Here, we present the atomic models of …
produced by the mitochondrial F1Fo ATP synthase. Here, we present the atomic models of …
Molecular basis of V-ATPase inhibition by bafilomycin A1
Pharmacological inhibition of vacuolar-type H+-ATPase (V-ATPase) by its specific inhibitor
can abrogate tumor metastasis, prevent autophagy, and reduce cellular signaling …
can abrogate tumor metastasis, prevent autophagy, and reduce cellular signaling …
Structure of V-ATPase from the mammalian brain
In neurons, the loading of neurotransmitters into synaptic vesicles uses energy from proton-
pumping vesicular-or vacuolar-type adenosine triphosphatases (V-ATPases). These …
pumping vesicular-or vacuolar-type adenosine triphosphatases (V-ATPases). These …
The V-ATPases in cancer and cell death
Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …
Structure and Roles of V-type ATPases
T Vasanthakumar, JL Rubinstein - Trends in biochemical sciences, 2020 - cell.com
V-ATPases are membrane-embedded protein complexes that function as ATP hydrolysis-
driven proton pumps. V-ATPases are the primary source of organellar acidification in all …
driven proton pumps. V-ATPases are the primary source of organellar acidification in all …
Structures of a complete human V-ATPase reveal mechanisms of its assembly
Vesicular-or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton
pumps comprised of a cytoplasmic V 1 complex for ATP hydrolysis and a membrane …
pumps comprised of a cytoplasmic V 1 complex for ATP hydrolysis and a membrane …
Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1
The mitochondrial adenosine triphosphate (ATP) synthase produces most of the ATP
required by mammalian cells. We isolated porcine tetrameric ATP synthase and solved its …
required by mammalian cells. We isolated porcine tetrameric ATP synthase and solved its …
[HTML][HTML] Regulation and function of V-ATPases in physiology and disease
MP Collins, M Forgac - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2020 - Elsevier
Abstract The vacuolar H+-ATPases (V-ATPases) are essential, ATP-dependent proton
pumps present in a variety of eukaryotic cellular membranes. Intracellularly, V-ATPase …
pumps present in a variety of eukaryotic cellular membranes. Intracellularly, V-ATPase …